Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status
Aims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men. Methods. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecul...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2016/4131794 |
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| author | Michael W. J. Davie Sally F. Evans Christopher A. Sharp |
| author_facet | Michael W. J. Davie Sally F. Evans Christopher A. Sharp |
| author_sort | Michael W. J. Davie |
| collection | DOAJ |
| description | Aims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men. Methods. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular) and 2 diaphyseal (mainly cortical)). BMD at femoral neck (FN) and lumbar spine L2–4, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH), and urinary calcium and NTx/Cr, a measure of bone breakdown, were also measured. Age matched healthy men provided values for BMD calculation of z and T scores and for biochemical measurements. Results. Low BMD z scores were found at metaphyseal regions in the leg (p<0.001) and in the FN (p<0.05). The distal metaphyseal region BMD in the leg was lower than spine or FN (p<0.05). PTH, urinary calcium/creatinine, and urinary NTx/Cr were similar to controls. Both metaphyseal and diaphyseal BMD z scores were associated with body weight (p<0.02), but not with either PTH or urinary NTx/Cr. Conclusions. Low BMD lower limb regions comprising mostly trabecular bone occur early in CD and in the absence of elevated PTH or increased bone resorption. Low BMD is associated with low body weight. |
| format | Article |
| id | doaj-art-7f3801daca7f48d397e753f8fd8f06e3 |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-7f3801daca7f48d397e753f8fd8f06e32025-02-03T01:21:50ZengWileyJournal of Osteoporosis2090-80592042-00642016-01-01201610.1155/2016/41317944131794Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid StatusMichael W. J. Davie0Sally F. Evans1Christopher A. Sharp2Charles Salt Centre for Human Metabolism, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry SY10 7AG, UKCharles Salt Centre for Human Metabolism, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry SY10 7AG, UKInstitute of Medicine, University Centre Shrewsbury, University of Chester, The Guildhall, Frankwell Quay, Shrewsbury, Shropshire SY3 8HQ, UKAims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men. Methods. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular) and 2 diaphyseal (mainly cortical)). BMD at femoral neck (FN) and lumbar spine L2–4, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH), and urinary calcium and NTx/Cr, a measure of bone breakdown, were also measured. Age matched healthy men provided values for BMD calculation of z and T scores and for biochemical measurements. Results. Low BMD z scores were found at metaphyseal regions in the leg (p<0.001) and in the FN (p<0.05). The distal metaphyseal region BMD in the leg was lower than spine or FN (p<0.05). PTH, urinary calcium/creatinine, and urinary NTx/Cr were similar to controls. Both metaphyseal and diaphyseal BMD z scores were associated with body weight (p<0.02), but not with either PTH or urinary NTx/Cr. Conclusions. Low BMD lower limb regions comprising mostly trabecular bone occur early in CD and in the absence of elevated PTH or increased bone resorption. Low BMD is associated with low body weight.http://dx.doi.org/10.1155/2016/4131794 |
| spellingShingle | Michael W. J. Davie Sally F. Evans Christopher A. Sharp Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status Journal of Osteoporosis |
| title | Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status |
| title_full | Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status |
| title_fullStr | Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status |
| title_full_unstemmed | Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status |
| title_short | Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status |
| title_sort | lower limb metaphyseal bone is lost in men with coeliac disease and does not relate to parathyroid status |
| url | http://dx.doi.org/10.1155/2016/4131794 |
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