Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review
Hemochromatosis is an autosomal recessive disorder which leads to abnormal iron deposition in the parenchyma of multiple organs causing tissue damage. Accumulation of iron in the brain has been postulated to be associated with several neurodegenerative diseases including Parkinson’s disease. The exc...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/5146723 |
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| _version_ | 1832550084270620672 |
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| author | Tarun Girotra Abhimanyu Mahajan Christos Sidiropoulos |
| author_facet | Tarun Girotra Abhimanyu Mahajan Christos Sidiropoulos |
| author_sort | Tarun Girotra |
| collection | DOAJ |
| description | Hemochromatosis is an autosomal recessive disorder which leads to abnormal iron deposition in the parenchyma of multiple organs causing tissue damage. Accumulation of iron in the brain has been postulated to be associated with several neurodegenerative diseases including Parkinson’s disease. The excess iron promotes Parkin and α-synuclein aggregation in the neurons. Excess iron has also been noted in substantia nigra on MRI especially using susceptibility weighted imaging in patients with Parkinson’s disease. We present a case of a young male with alleles for both C282Y and H63D who presented with signs of Parkinsonism and demonstrated significant improvement with levodopa treatment. |
| format | Article |
| id | doaj-art-7f376aca5daf41b98be5aa9c2aba3758 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-7f376aca5daf41b98be5aa9c2aba37582025-02-03T06:07:50ZengWileyCase Reports in Neurological Medicine2090-66682090-66762017-01-01201710.1155/2017/51467235146723Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature ReviewTarun Girotra0Abhimanyu Mahajan1Christos Sidiropoulos2Department of Neurology, Henry Ford Hospital, Detroit, MI, USADepartment of Neurology, Henry Ford Hospital, Detroit, MI, USADepartment of Neurology and Ophthalmology, Michigan State University, East Lansing, MI, USAHemochromatosis is an autosomal recessive disorder which leads to abnormal iron deposition in the parenchyma of multiple organs causing tissue damage. Accumulation of iron in the brain has been postulated to be associated with several neurodegenerative diseases including Parkinson’s disease. The excess iron promotes Parkin and α-synuclein aggregation in the neurons. Excess iron has also been noted in substantia nigra on MRI especially using susceptibility weighted imaging in patients with Parkinson’s disease. We present a case of a young male with alleles for both C282Y and H63D who presented with signs of Parkinsonism and demonstrated significant improvement with levodopa treatment.http://dx.doi.org/10.1155/2017/5146723 |
| spellingShingle | Tarun Girotra Abhimanyu Mahajan Christos Sidiropoulos Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review Case Reports in Neurological Medicine |
| title | Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review |
| title_full | Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review |
| title_fullStr | Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review |
| title_full_unstemmed | Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review |
| title_short | Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review |
| title_sort | levodopa responsive parkinsonism in patients with hemochromatosis case presentation and literature review |
| url | http://dx.doi.org/10.1155/2017/5146723 |
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