Parkinson’s Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson’s Disease, If Anything?
Technologies allowing for the derivation of patient-specific neurons from somatic cells are emerging as powerful in vitro tools to investigate the intrinsic cellular pathological behaviours of the diseases that affect these patients. While the use of patient-derived neurons to model Parkinson’s dise...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/926147 |
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| _version_ | 1832562957039435776 |
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| author | J. Drouin-Ouellet R. A. Barker |
| author_facet | J. Drouin-Ouellet R. A. Barker |
| author_sort | J. Drouin-Ouellet |
| collection | DOAJ |
| description | Technologies allowing for the derivation of patient-specific neurons from somatic cells are emerging as powerful in vitro tools to investigate the intrinsic cellular pathological behaviours of the diseases that affect these patients. While the use of patient-derived neurons to model Parkinson’s disease (PD) has only just begun, these approaches have allowed us to begin investigating disease pathogenesis in a unique way. In this paper, we discuss the advances made in the field of cellular reprogramming to model PD and discuss the pros and cons associated with the use of such cells. |
| format | Article |
| id | doaj-art-7f2a8027234c428a9353a149b42ee279 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-7f2a8027234c428a9353a149b42ee2792025-02-03T01:21:20ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/926147926147Parkinson’s Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson’s Disease, If Anything?J. Drouin-Ouellet0R. A. Barker1Neuroscience Axis, CHUL Research Center (CHUQ), T2-50, 2705 Boul. Laurier, Quebec City, QC, G1V 4G2, CanadaDepartment of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UKTechnologies allowing for the derivation of patient-specific neurons from somatic cells are emerging as powerful in vitro tools to investigate the intrinsic cellular pathological behaviours of the diseases that affect these patients. While the use of patient-derived neurons to model Parkinson’s disease (PD) has only just begun, these approaches have allowed us to begin investigating disease pathogenesis in a unique way. In this paper, we discuss the advances made in the field of cellular reprogramming to model PD and discuss the pros and cons associated with the use of such cells.http://dx.doi.org/10.1155/2012/926147 |
| spellingShingle | J. Drouin-Ouellet R. A. Barker Parkinson’s Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson’s Disease, If Anything? Stem Cells International |
| title | Parkinson’s Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson’s Disease, If Anything? |
| title_full | Parkinson’s Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson’s Disease, If Anything? |
| title_fullStr | Parkinson’s Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson’s Disease, If Anything? |
| title_full_unstemmed | Parkinson’s Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson’s Disease, If Anything? |
| title_short | Parkinson’s Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson’s Disease, If Anything? |
| title_sort | parkinson s disease in a dish what patient specific reprogrammed somatic cells can tell us about parkinson s disease if anything |
| url | http://dx.doi.org/10.1155/2012/926147 |
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