Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity
In the present study behavioral effects of the 5-HT2C serotonin receptor were investigated in different mouse strains. The 5-HT2C receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect wa...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/846589 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558186604789760 |
|---|---|
| author | Darya V. Bazovkina Elena M. Kondaurova Vladimir S. Naumenko Evgeni Ponimaskin |
| author_facet | Darya V. Bazovkina Elena M. Kondaurova Vladimir S. Naumenko Evgeni Ponimaskin |
| author_sort | Darya V. Bazovkina |
| collection | DOAJ |
| description | In the present study behavioral effects of the 5-HT2C serotonin receptor were investigated in different mouse strains. The 5-HT2C receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect was receptor-specific because it was inhibited by the 5-HT2C receptor antagonist RS102221. To study the role of genotype in 5-HT2C receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment. We found that the 5-HT2C receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice. We also compared the interstrain differences in functional response to 5-HT2C and 5-HT2A receptors activation measured by the quantification of receptor-mediated head-twitches. These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains. Moreover, we found that 5-HT2A receptor activation with DOI did not change locomotor activity in CBA/Lac mice. Taken together, our data indicate the implication of 5-HT2C receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT2C and 5-HT2A receptors. |
| format | Article |
| id | doaj-art-7f229d22123c4dd4b4dfcea71aa0ffc0 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7f229d22123c4dd4b4dfcea71aa0ffc02025-02-03T01:33:03ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/846589846589Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional ActivityDarya V. Bazovkina0Elena M. Kondaurova1Vladimir S. Naumenko2Evgeni Ponimaskin3Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk 630090, RussiaInstitute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk 630090, RussiaInstitute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk 630090, RussiaCellular Neurophysiology, Hannover Medical School, 30625 Hannover, GermanyIn the present study behavioral effects of the 5-HT2C serotonin receptor were investigated in different mouse strains. The 5-HT2C receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect was receptor-specific because it was inhibited by the 5-HT2C receptor antagonist RS102221. To study the role of genotype in 5-HT2C receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment. We found that the 5-HT2C receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice. We also compared the interstrain differences in functional response to 5-HT2C and 5-HT2A receptors activation measured by the quantification of receptor-mediated head-twitches. These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains. Moreover, we found that 5-HT2A receptor activation with DOI did not change locomotor activity in CBA/Lac mice. Taken together, our data indicate the implication of 5-HT2C receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT2C and 5-HT2A receptors.http://dx.doi.org/10.1155/2015/846589 |
| spellingShingle | Darya V. Bazovkina Elena M. Kondaurova Vladimir S. Naumenko Evgeni Ponimaskin Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity Neural Plasticity |
| title | Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity |
| title_full | Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity |
| title_fullStr | Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity |
| title_full_unstemmed | Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity |
| title_short | Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity |
| title_sort | genotype dependent difference in 5 ht2c receptor induced hypolocomotion comparison with 5 ht2a receptor functional activity |
| url | http://dx.doi.org/10.1155/2015/846589 |
| work_keys_str_mv | AT daryavbazovkina genotypedependentdifferencein5ht2creceptorinducedhypolocomotioncomparisonwith5ht2areceptorfunctionalactivity AT elenamkondaurova genotypedependentdifferencein5ht2creceptorinducedhypolocomotioncomparisonwith5ht2areceptorfunctionalactivity AT vladimirsnaumenko genotypedependentdifferencein5ht2creceptorinducedhypolocomotioncomparisonwith5ht2areceptorfunctionalactivity AT evgeniponimaskin genotypedependentdifferencein5ht2creceptorinducedhypolocomotioncomparisonwith5ht2areceptorfunctionalactivity |