The efficacy of the combination drug of hydroxymethylquinoxalinedioxide + isoniazid lyophilisate in the treatment of bronchial tuberculosis
The objective of the study: to evaluate the safety and efficacy of the combination drug of hydroxymethylquinoxalinedioxide + isoniazid lyophilisate within chemotherapy of patients with bronchial tuberculosis complicating pulmonary tuberculosis.Subjects and methods. Adverse effects of the combination...
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| Main Author: | |
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| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2019-05-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1259 |
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| Summary: | The objective of the study: to evaluate the safety and efficacy of the combination drug of hydroxymethylquinoxalinedioxide + isoniazid lyophilisate within chemotherapy of patients with bronchial tuberculosis complicating pulmonary tuberculosis.Subjects and methods. Adverse effects of the combination drug were studied in 26 patients with bronchial and pulmonary tuberculosis who had inhalations with hydroxymethylquinoxalinedioxide + isoniazid lyophilisate.The treatment efficacy of bronchial tuberculosis was compared in Group I (24 patients who received basic therapy for tuberculosis and inhalation) versus Group II (34 patients who received basic therapy only).Results. Adverse events occurred in 4/26 patients (15.4%, 95% CI 5.5-34.2%) who had inhalations with a solution of hydroxymethylquinoxalinedioxide + isoniazid lyophilisate due to bronchial tuberculosis, 2/26 (7.7 % 95% CI 1.0-25.3%) had to have the drug discontinued. Treatment efficacy of bronchial tuberculosis was statistically significantly higher in patients from Group I (based on endoscopy data) compared to Group II (after 1 month of treatment, 20/24 (83.3%) and 14/34 (41.2%), respectively; p = 0.001 Fischer’s Exact test; after 6 months 23/24 (95.8%) and 26/34 (76.5%), respectively; p = 0.041 Fischer’s Exact test). |
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| ISSN: | 2075-1230 2542-1506 |