Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing
The globus pallidus (GP) plays a key role in the overall basal ganglia (BG) activity. Despite evidence of cholinergic inputs to GP, their role in the spiking activity of GP neurons has not received attention. We examine the effect of local activation and blockade of muscarinic receptors (MRs) in the...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/547638 |
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| author | Enrique Querejeta Alberto Alatorre Alain Ríos Rafael Barrientos Aldo Oviedo-Chávez Rosa Amalia Bobadilla-Lugo Alfonso Delgado |
| author_facet | Enrique Querejeta Alberto Alatorre Alain Ríos Rafael Barrientos Aldo Oviedo-Chávez Rosa Amalia Bobadilla-Lugo Alfonso Delgado |
| author_sort | Enrique Querejeta |
| collection | DOAJ |
| description | The globus pallidus (GP) plays a key role in the overall basal ganglia (BG) activity. Despite evidence of cholinergic inputs to GP, their role in the spiking activity of GP neurons has not received attention. We examine the effect of local activation and blockade of muscarinic receptors (MRs) in the spontaneous firing of GP neurons both in normal and ipsilateral striatum-lesioned rats. We found that activation of MRs produces heterogeneous responses in both normal and ipsilateral striatum-lesioned rats: in normal rats the response evoked by MRs depends on the predrug basal firing rate; the inhibition evoked by MRs is higher in normal rats than in striatum-lesioned rats; the number of neurons that undergo inhibition is lower in striatum-lesioned rats than in normal rats. Our data suggest that modulation of MRs in the GP depends on the firing rate before their activation and on the integrity of the striato-pallidal pathway. |
| format | Article |
| id | doaj-art-7ef9b8ef78de4bf19cd9c3c7988ba330 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7ef9b8ef78de4bf19cd9c3c7988ba3302025-02-03T01:27:38ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/547638547638Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal FiringEnrique Querejeta0Alberto Alatorre1Alain Ríos2Rafael Barrientos3Aldo Oviedo-Chávez4Rosa Amalia Bobadilla-Lugo5Alfonso Delgado6Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 México, DF, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 México, DF, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 México, DF, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 México, DF, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 México, DF, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 México, DF, MexicoDepartamento de Fisiología, Facultad de Medicina Universidad Autónoma de Chihuahua, Circuito Universitario Campus II, 31125 Chihuahua, Chih, MexicoThe globus pallidus (GP) plays a key role in the overall basal ganglia (BG) activity. Despite evidence of cholinergic inputs to GP, their role in the spiking activity of GP neurons has not received attention. We examine the effect of local activation and blockade of muscarinic receptors (MRs) in the spontaneous firing of GP neurons both in normal and ipsilateral striatum-lesioned rats. We found that activation of MRs produces heterogeneous responses in both normal and ipsilateral striatum-lesioned rats: in normal rats the response evoked by MRs depends on the predrug basal firing rate; the inhibition evoked by MRs is higher in normal rats than in striatum-lesioned rats; the number of neurons that undergo inhibition is lower in striatum-lesioned rats than in normal rats. Our data suggest that modulation of MRs in the GP depends on the firing rate before their activation and on the integrity of the striato-pallidal pathway.http://dx.doi.org/10.1100/2012/547638 |
| spellingShingle | Enrique Querejeta Alberto Alatorre Alain Ríos Rafael Barrientos Aldo Oviedo-Chávez Rosa Amalia Bobadilla-Lugo Alfonso Delgado Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing The Scientific World Journal |
| title | Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing |
| title_full | Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing |
| title_fullStr | Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing |
| title_full_unstemmed | Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing |
| title_short | Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing |
| title_sort | striatal input and rate dependent effects of muscarinic receptors on pallidal firing |
| url | http://dx.doi.org/10.1100/2012/547638 |
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