Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics
In the current era, malnutrition is seen as both undernutrition and overweight and obesity; both conditions are caused by nutrient deficiency or excess and improper use or imbalance in the intake of macro and micronutrients. Recent evidence suggests that malnutrition alters the intestinal microbiota...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/179 |
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| author | Monica Profir Robert Mihai Enache Oana Alexandra Roşu Luciana Alexandra Pavelescu Sanda Maria Creţoiu Bogdan Severus Gaspar |
| author_facet | Monica Profir Robert Mihai Enache Oana Alexandra Roşu Luciana Alexandra Pavelescu Sanda Maria Creţoiu Bogdan Severus Gaspar |
| author_sort | Monica Profir |
| collection | DOAJ |
| description | In the current era, malnutrition is seen as both undernutrition and overweight and obesity; both conditions are caused by nutrient deficiency or excess and improper use or imbalance in the intake of macro and micronutrients. Recent evidence suggests that malnutrition alters the intestinal microbiota, known as dysbiosis. Secretory immunoglobulin A (sIgA) plays an important role in maintaining and increasing beneficial intestinal microbiota populations and protecting against pathogenic species. Depletion of beneficial bacterial populations throughout life is also conditioned by malnutrition. This review aims to synthesize the evidence that establishes an interrelationship between diet, malnutrition, changes in the intestinal flora, and sIgA levels. Targeted nutritional therapies combined with prebiotic, probiotic, and postbiotic administration can restore the immune response in the intestine and the host’s homeostasis. |
| format | Article |
| id | doaj-art-7ef6d686e552442593f6d47c62908f56 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-7ef6d686e552442593f6d47c62908f562025-01-24T13:24:17ZengMDPI AGBiomedicines2227-90592025-01-0113117910.3390/biomedicines13010179Malnutrition and Its Influence on Gut sIgA–Microbiota DynamicsMonica Profir0Robert Mihai Enache1Oana Alexandra Roşu2Luciana Alexandra Pavelescu3Sanda Maria Creţoiu4Bogdan Severus Gaspar5Department of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, RomaniaDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Surgery, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaIn the current era, malnutrition is seen as both undernutrition and overweight and obesity; both conditions are caused by nutrient deficiency or excess and improper use or imbalance in the intake of macro and micronutrients. Recent evidence suggests that malnutrition alters the intestinal microbiota, known as dysbiosis. Secretory immunoglobulin A (sIgA) plays an important role in maintaining and increasing beneficial intestinal microbiota populations and protecting against pathogenic species. Depletion of beneficial bacterial populations throughout life is also conditioned by malnutrition. This review aims to synthesize the evidence that establishes an interrelationship between diet, malnutrition, changes in the intestinal flora, and sIgA levels. Targeted nutritional therapies combined with prebiotic, probiotic, and postbiotic administration can restore the immune response in the intestine and the host’s homeostasis.https://www.mdpi.com/2227-9059/13/1/179malnutritiongut microbiotaobesityoverweightunderweightsecretory IgA |
| spellingShingle | Monica Profir Robert Mihai Enache Oana Alexandra Roşu Luciana Alexandra Pavelescu Sanda Maria Creţoiu Bogdan Severus Gaspar Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics Biomedicines malnutrition gut microbiota obesity overweight underweight secretory IgA |
| title | Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics |
| title_full | Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics |
| title_fullStr | Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics |
| title_full_unstemmed | Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics |
| title_short | Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics |
| title_sort | malnutrition and its influence on gut siga microbiota dynamics |
| topic | malnutrition gut microbiota obesity overweight underweight secretory IgA |
| url | https://www.mdpi.com/2227-9059/13/1/179 |
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