Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic Applications
In this study, a manual micro-valve system (dimension: w × h: 1000 × 50 μm with 8-integrated channel valves was designed for controlling up to 8 different flows of agents (including magnetic nanoparticle flow) injected into the mixture zone of the microfluidics. The working parts of the micro-valve...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2020/2460212 |
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| _version_ | 1832566249561784320 |
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| author | Tu N. Le Van-Anh Nguyen Giang L. Bach Lam D. Tran Ha H. Cao |
| author_facet | Tu N. Le Van-Anh Nguyen Giang L. Bach Lam D. Tran Ha H. Cao |
| author_sort | Tu N. Le |
| collection | DOAJ |
| description | In this study, a manual micro-valve system (dimension: w × h: 1000 × 50 μm with 8-integrated channel valves was designed for controlling up to 8 different flows of agents (including magnetic nanoparticle flow) injected into the mixture zone of the microfluidics. The working parts of the micro-valve and microfluidic channel were fabricated from Poly(dimethyl siloxane) materials. The aperture of each channel valve was manually manipulated by a screw and a support kit (made of Plexiglas® materials). This valve system was connected to a microfluidic device with two important modules: a multi-liquid mixing component and a micro-reactor (~5 μL of volume). The study on controlling liquid flows proved that this valve system was effective for the experiments on the flow mixing and delivering the reactants into the micro-reaction chamber in order. The results are the first step for the fabrication of liquid flow controllers in integrated microfluidic systems towards biological analysis applications. |
| format | Article |
| id | doaj-art-7ef4c8143c6f45759d82546882c83c15 |
| institution | Kabale University |
| issn | 0730-6679 1098-2329 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-7ef4c8143c6f45759d82546882c83c152025-02-03T01:04:41ZengWileyAdvances in Polymer Technology0730-66791098-23292020-01-01202010.1155/2020/24602122460212Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic ApplicationsTu N. Le0Van-Anh Nguyen1Giang L. Bach2Lam D. Tran3Ha H. Cao4National Psychiatric Hospital No. 1, Hanoi, VietnamSchool of Chemical Engineering, Hanoi University of Science and Technology (HUST), Hanoi, VietnamNguyen Tat Thanh University, Ho Chi Minh City, VietnamInstitute for Tropical Technology, Hanoi, VietnamSchool of Chemical Engineering, Hanoi University of Science and Technology (HUST), Hanoi, VietnamIn this study, a manual micro-valve system (dimension: w × h: 1000 × 50 μm with 8-integrated channel valves was designed for controlling up to 8 different flows of agents (including magnetic nanoparticle flow) injected into the mixture zone of the microfluidics. The working parts of the micro-valve and microfluidic channel were fabricated from Poly(dimethyl siloxane) materials. The aperture of each channel valve was manually manipulated by a screw and a support kit (made of Plexiglas® materials). This valve system was connected to a microfluidic device with two important modules: a multi-liquid mixing component and a micro-reactor (~5 μL of volume). The study on controlling liquid flows proved that this valve system was effective for the experiments on the flow mixing and delivering the reactants into the micro-reaction chamber in order. The results are the first step for the fabrication of liquid flow controllers in integrated microfluidic systems towards biological analysis applications.http://dx.doi.org/10.1155/2020/2460212 |
| spellingShingle | Tu N. Le Van-Anh Nguyen Giang L. Bach Lam D. Tran Ha H. Cao Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic Applications Advances in Polymer Technology |
| title | Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic Applications |
| title_full | Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic Applications |
| title_fullStr | Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic Applications |
| title_full_unstemmed | Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic Applications |
| title_short | Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic Applications |
| title_sort | design and fabrication of a pdms based manual micro valve system for microfluidic applications |
| url | http://dx.doi.org/10.1155/2020/2460212 |
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