A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis
BackgroundBasil is a widely used herb in Persian medicine and is gaining recognition as a functional food worldwide.Aim of the studyThis trial aimed to assess the effectiveness of a traditional formulation of basil oil in comparison with diclofenac gel in treating knee osteoarthritis, considering it...
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Frontiers Media S.A.
2024-05-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1377527/full |
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| author | Alireza Askari Fatemeh Sadat Hasheminasab Fatemeh Sadat Hasheminasab Omid Sadeghpour Mohammad Mehdi Naghizadehd Seyed Ali Ravansalar Aida Iraji Mohammad Hashem Hashempur |
| author_facet | Alireza Askari Fatemeh Sadat Hasheminasab Fatemeh Sadat Hasheminasab Omid Sadeghpour Mohammad Mehdi Naghizadehd Seyed Ali Ravansalar Aida Iraji Mohammad Hashem Hashempur |
| author_sort | Alireza Askari |
| collection | DOAJ |
| description | BackgroundBasil is a widely used herb in Persian medicine and is gaining recognition as a functional food worldwide.Aim of the studyThis trial aimed to assess the effectiveness of a traditional formulation of basil oil in comparison with diclofenac gel in treating knee osteoarthritis, considering its established anti-inflammatory, anti-nociceptive, and anti-oxidative properties.Materials and methodsOne hundred eligible patients were equally randomized to the traditional basil oil (containing sesame oil) and diclofenac gel groups. They used their respective topical treatments thrice daily for 4 weeks. Various measurements were taken at the beginning of the study, 2, and 4 weeks after starting the intervention, including the 8-m walk test, knee pain (based on visual analog scale), flexion angle of the knee joint, analgesic consumption, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.ResultsNo significant differences were observed between the basil oil and diclofenac gel groups in any of the measured outcomes. However, significant improvements were noted within each group for most variables.ConclusionTopical application of the traditional formulation of basil oil appears to improve clinical symptoms and certain functional indicators of knee osteoarthritis to a similar extent as diclofenac gel. This suggests that basil oil could be considered an effective management option for this condition.Clinical Trial Registration:https://irct.behdasht.gov.ir/, identifier IRCT2017081711341N7. |
| format | Article |
| id | doaj-art-7ed01b49909e4d46b8bf6ea255273171 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-7ed01b49909e4d46b8bf6ea2552731712025-01-27T10:11:57ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-05-011510.3389/fphar.2024.13775271377527A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritisAlireza Askari0Fatemeh Sadat Hasheminasab1Fatemeh Sadat Hasheminasab2Omid Sadeghpour3Mohammad Mehdi Naghizadehd4Seyed Ali Ravansalar5Aida Iraji6Mohammad Hashem Hashempur7Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, IranPharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Genetic, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranResearch Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranResearch Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranBackgroundBasil is a widely used herb in Persian medicine and is gaining recognition as a functional food worldwide.Aim of the studyThis trial aimed to assess the effectiveness of a traditional formulation of basil oil in comparison with diclofenac gel in treating knee osteoarthritis, considering its established anti-inflammatory, anti-nociceptive, and anti-oxidative properties.Materials and methodsOne hundred eligible patients were equally randomized to the traditional basil oil (containing sesame oil) and diclofenac gel groups. They used their respective topical treatments thrice daily for 4 weeks. Various measurements were taken at the beginning of the study, 2, and 4 weeks after starting the intervention, including the 8-m walk test, knee pain (based on visual analog scale), flexion angle of the knee joint, analgesic consumption, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.ResultsNo significant differences were observed between the basil oil and diclofenac gel groups in any of the measured outcomes. However, significant improvements were noted within each group for most variables.ConclusionTopical application of the traditional formulation of basil oil appears to improve clinical symptoms and certain functional indicators of knee osteoarthritis to a similar extent as diclofenac gel. This suggests that basil oil could be considered an effective management option for this condition.Clinical Trial Registration:https://irct.behdasht.gov.ir/, identifier IRCT2017081711341N7.https://www.frontiersin.org/articles/10.3389/fphar.2024.1377527/fullosteoarthritisherbal medicinetraditional Persian medicinebasilOcimum basilicum |
| spellingShingle | Alireza Askari Fatemeh Sadat Hasheminasab Fatemeh Sadat Hasheminasab Omid Sadeghpour Mohammad Mehdi Naghizadehd Seyed Ali Ravansalar Aida Iraji Mohammad Hashem Hashempur A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis Frontiers in Pharmacology osteoarthritis herbal medicine traditional Persian medicine basil Ocimum basilicum |
| title | A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis |
| title_full | A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis |
| title_fullStr | A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis |
| title_full_unstemmed | A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis |
| title_short | A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis |
| title_sort | randomized double blind active controlled clinical trial on the efficacy of topical basil ocimum basilicum oil in knee osteoarthritis |
| topic | osteoarthritis herbal medicine traditional Persian medicine basil Ocimum basilicum |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1377527/full |
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