Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal study (CHARLS)
Objective: As the population ages, concerns about cognitive decline have become increasingly relevant in medical consultations. This study aims to analyze the interaction between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults, providing a theoretical b...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664624001852 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832573224262565888 |
|---|---|
| author | Yixuan Ma Xinze Wu Yinjiao Zhao Weihao Hong Yisheng Luan Peiyu Song Bing Zhang |
| author_facet | Yixuan Ma Xinze Wu Yinjiao Zhao Weihao Hong Yisheng Luan Peiyu Song Bing Zhang |
| author_sort | Yixuan Ma |
| collection | DOAJ |
| description | Objective: As the population ages, concerns about cognitive decline have become increasingly relevant in medical consultations. This study aims to analyze the interaction between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults, providing a theoretical basis for better prevention of cognitive decline. Methods: This study used data from the China Health and Retirement Longitudinal Study (CHARLS) wave 3, including 13 716 participants aged 45 years or older. Cognitive function was assessed through two dimensions, resulting in a total score ranging from 0 to 31 points, with higher scores indicating better cognitive function. Muscle strength was measured using normalized grip strength and chair-standing time, while lung function was evaluated using peak expiratory flow (PEF). Results: Total cognitive function scores exhibited significant correlations with grip strength, chair-standing time, and PEF. Muscle strength and lung function demonstrated significant associations with cognitive function, with lung function emerging as a notable mediating factor. This relationship persisted even after adjusting for potential confounding variables. Specifically, PEF played a substantial mediating role in linking grip strength to cognitive function scores (estimated indirect effect = 0.0132, boot-strapped standard error = 0.0015, boot-strapped standard 95% confidence interval = 0.0104, 0.0162). Additionally, PEF served as a significant mediator in the association between chair-standing time and cognitive function scores (estimated indirect effect = −0.0204, boot-strapped standard error = 0.0023, boot-strapped standard 95% confidence interval = −0.0251, −0.0159). Conclusion: The study highlights the importance of addressing declines in muscle strength and lung function to identify risk factors associated with cognitive function. Understanding these relationships can provide insights into potential pathways linking these variables and may aid in better prevention of cognitive decline. Further long-term longitudinal cohort studies are needed to explore the causality between these factors. |
| format | Article |
| id | doaj-art-7ecfca745f5548fea312d91d8d3f56ed |
| institution | Kabale University |
| issn | 0929-6646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj-art-7ecfca745f5548fea312d91d8d3f56ed2025-02-02T05:26:46ZengElsevierJournal of the Formosan Medical Association0929-66462025-02-011242171177Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal study (CHARLS)Yixuan Ma0Xinze Wu1Yinjiao Zhao2Weihao Hong3Yisheng Luan4Peiyu Song5Bing Zhang6Division of Sports Science and Physical Education, Tsinghua University, Beijing, ChinaDepartment of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Rehabilitation Medicine, Jiangwan Hospital of Shanghai, Hongkou District, Shanghai, ChinaDivision of Sports Science and Physical Education, Tsinghua University, Beijing, ChinaDivision of Sports Science and Physical Education, Tsinghua University, Beijing, ChinaDepartment of Rehabilitation Medicine, Jiangwan Hospital of Shanghai, Hongkou District, Shanghai, China; Corresponding author. Jiangwan Hospital, No. 1878 North Sichuan Road, Hongkou District, Shanghai, China.Division of Sports Science and Physical Education, Tsinghua University, Beijing, China; Corresponding author. Division of Sports Science and Physical Education, Tsinghua University, Beijing, 100081, China.Objective: As the population ages, concerns about cognitive decline have become increasingly relevant in medical consultations. This study aims to analyze the interaction between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults, providing a theoretical basis for better prevention of cognitive decline. Methods: This study used data from the China Health and Retirement Longitudinal Study (CHARLS) wave 3, including 13 716 participants aged 45 years or older. Cognitive function was assessed through two dimensions, resulting in a total score ranging from 0 to 31 points, with higher scores indicating better cognitive function. Muscle strength was measured using normalized grip strength and chair-standing time, while lung function was evaluated using peak expiratory flow (PEF). Results: Total cognitive function scores exhibited significant correlations with grip strength, chair-standing time, and PEF. Muscle strength and lung function demonstrated significant associations with cognitive function, with lung function emerging as a notable mediating factor. This relationship persisted even after adjusting for potential confounding variables. Specifically, PEF played a substantial mediating role in linking grip strength to cognitive function scores (estimated indirect effect = 0.0132, boot-strapped standard error = 0.0015, boot-strapped standard 95% confidence interval = 0.0104, 0.0162). Additionally, PEF served as a significant mediator in the association between chair-standing time and cognitive function scores (estimated indirect effect = −0.0204, boot-strapped standard error = 0.0023, boot-strapped standard 95% confidence interval = −0.0251, −0.0159). Conclusion: The study highlights the importance of addressing declines in muscle strength and lung function to identify risk factors associated with cognitive function. Understanding these relationships can provide insights into potential pathways linking these variables and may aid in better prevention of cognitive decline. Further long-term longitudinal cohort studies are needed to explore the causality between these factors.http://www.sciencedirect.com/science/article/pii/S0929664624001852Cognitive functionMuscle strengthLung functionMediating role |
| spellingShingle | Yixuan Ma Xinze Wu Yinjiao Zhao Weihao Hong Yisheng Luan Peiyu Song Bing Zhang Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal study (CHARLS) Journal of the Formosan Medical Association Cognitive function Muscle strength Lung function Mediating role |
| title | Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal study (CHARLS) |
| title_full | Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal study (CHARLS) |
| title_fullStr | Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal study (CHARLS) |
| title_full_unstemmed | Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal study (CHARLS) |
| title_short | Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal study (CHARLS) |
| title_sort | relationships between muscle strength lung function and cognitive function in chinese middle aged and older adults a study based on the china health and retirement longitudinal study charls |
| topic | Cognitive function Muscle strength Lung function Mediating role |
| url | http://www.sciencedirect.com/science/article/pii/S0929664624001852 |
| work_keys_str_mv | AT yixuanma relationshipsbetweenmusclestrengthlungfunctionandcognitivefunctioninchinesemiddleagedandolderadultsastudybasedonthechinahealthandretirementlongitudinalstudycharls AT xinzewu relationshipsbetweenmusclestrengthlungfunctionandcognitivefunctioninchinesemiddleagedandolderadultsastudybasedonthechinahealthandretirementlongitudinalstudycharls AT yinjiaozhao relationshipsbetweenmusclestrengthlungfunctionandcognitivefunctioninchinesemiddleagedandolderadultsastudybasedonthechinahealthandretirementlongitudinalstudycharls AT weihaohong relationshipsbetweenmusclestrengthlungfunctionandcognitivefunctioninchinesemiddleagedandolderadultsastudybasedonthechinahealthandretirementlongitudinalstudycharls AT yishengluan relationshipsbetweenmusclestrengthlungfunctionandcognitivefunctioninchinesemiddleagedandolderadultsastudybasedonthechinahealthandretirementlongitudinalstudycharls AT peiyusong relationshipsbetweenmusclestrengthlungfunctionandcognitivefunctioninchinesemiddleagedandolderadultsastudybasedonthechinahealthandretirementlongitudinalstudycharls AT bingzhang relationshipsbetweenmusclestrengthlungfunctionandcognitivefunctioninchinesemiddleagedandolderadultsastudybasedonthechinahealthandretirementlongitudinalstudycharls |