PKM2-mediated metabolic reprogramming of microglia in neuroinflammation

Abstract Microglia, the resident immune cells of the central nervous system, undergo metabolic reprogramming during neuroinflammation, playing a crucial role in the pathogenesis of neurological disorders such as Parkinson’s disease. This review focuses on Pyruvate Kinase M2 (PKM2), a key glycolytic...

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Bibliographic Details
Main Authors: Qi Zhang, Sha-Sha Wang, Zhao Zhang, Shi-Feng Chu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02453-5
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