Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals
In spite of significant advancements in diagnosis and treatment, cancer remains one of the major threats to human health due to its ability to cause disease with high morbidity and mortality. A multifactorial and multitargeted approach is required towards intervention of the multitude of signaling p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/12/1/7 |
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| author | Ghyda Murad Hashim Mehdi Shahgolzari Kathleen Hefferon Afagh Yavari Srividhya Venkataraman |
| author_facet | Ghyda Murad Hashim Mehdi Shahgolzari Kathleen Hefferon Afagh Yavari Srividhya Venkataraman |
| author_sort | Ghyda Murad Hashim |
| collection | DOAJ |
| description | In spite of significant advancements in diagnosis and treatment, cancer remains one of the major threats to human health due to its ability to cause disease with high morbidity and mortality. A multifactorial and multitargeted approach is required towards intervention of the multitude of signaling pathways associated with carcinogenesis inclusive of angiogenesis and metastasis. In this context, plants provide an immense source of phytotherapeutics that show great promise as anticancer drugs. There is increasing epidemiological data indicating that diets rich in vegetables and fruits could decrease the risks of certain cancers. Several studies have proved that natural plant polyphenols, such as flavonoids, lignans, phenolic acids, alkaloids, phenylpropanoids, isoprenoids, terpenes, and stilbenes, could be used in anticancer prophylaxis and therapeutics by recruitment of mechanisms inclusive of antioxidant and anti-inflammatory activities and modulation of several molecular events associated with carcinogenesis. The current review discusses the anticancer activities of principal phytochemicals with focus on signaling circuits towards targeted cancer prophylaxis and therapy. Also addressed are plant-derived anti-cancer vaccines, nanoparticles, monoclonal antibodies, and immunotherapies. This review article brings to light the importance of plants and plant-based platforms as invaluable, low-cost sources of anti-cancer molecules of particular applicability in resource-poor developing countries. |
| format | Article |
| id | doaj-art-7e99dee9a99248259c90d14f150f8007 |
| institution | Kabale University |
| issn | 2306-5354 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-7e99dee9a99248259c90d14f150f80072025-01-24T13:22:56ZengMDPI AGBioengineering2306-53542024-12-01121710.3390/bioengineering12010007Plant-Derived Anti-Cancer Therapeutics and BiopharmaceuticalsGhyda Murad Hashim0Mehdi Shahgolzari1Kathleen Hefferon2Afagh Yavari3Srividhya Venkataraman4Department of Cell & Systems Biology, University of Toronto, Toronto, ON M5S 3B2, CanadaDental Research Center, Hamadan University of Medical Sciences, Hamadan 65175-4171, IranDepartment of Cell & Systems Biology, University of Toronto, Toronto, ON M5S 3B2, CanadaDepartment of Biology, Payame Noor University, Tehran P.O. Box 19395-3697, IranDepartment of Cell & Systems Biology, University of Toronto, Toronto, ON M5S 3B2, CanadaIn spite of significant advancements in diagnosis and treatment, cancer remains one of the major threats to human health due to its ability to cause disease with high morbidity and mortality. A multifactorial and multitargeted approach is required towards intervention of the multitude of signaling pathways associated with carcinogenesis inclusive of angiogenesis and metastasis. In this context, plants provide an immense source of phytotherapeutics that show great promise as anticancer drugs. There is increasing epidemiological data indicating that diets rich in vegetables and fruits could decrease the risks of certain cancers. Several studies have proved that natural plant polyphenols, such as flavonoids, lignans, phenolic acids, alkaloids, phenylpropanoids, isoprenoids, terpenes, and stilbenes, could be used in anticancer prophylaxis and therapeutics by recruitment of mechanisms inclusive of antioxidant and anti-inflammatory activities and modulation of several molecular events associated with carcinogenesis. The current review discusses the anticancer activities of principal phytochemicals with focus on signaling circuits towards targeted cancer prophylaxis and therapy. Also addressed are plant-derived anti-cancer vaccines, nanoparticles, monoclonal antibodies, and immunotherapies. This review article brings to light the importance of plants and plant-based platforms as invaluable, low-cost sources of anti-cancer molecules of particular applicability in resource-poor developing countries.https://www.mdpi.com/2306-5354/12/1/7cancerphytochemicalsPVNPsVLPsMABsphototherapy |
| spellingShingle | Ghyda Murad Hashim Mehdi Shahgolzari Kathleen Hefferon Afagh Yavari Srividhya Venkataraman Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals Bioengineering cancer phytochemicals PVNPs VLPs MABs phototherapy |
| title | Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals |
| title_full | Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals |
| title_fullStr | Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals |
| title_full_unstemmed | Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals |
| title_short | Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals |
| title_sort | plant derived anti cancer therapeutics and biopharmaceuticals |
| topic | cancer phytochemicals PVNPs VLPs MABs phototherapy |
| url | https://www.mdpi.com/2306-5354/12/1/7 |
| work_keys_str_mv | AT ghydamuradhashim plantderivedanticancertherapeuticsandbiopharmaceuticals AT mehdishahgolzari plantderivedanticancertherapeuticsandbiopharmaceuticals AT kathleenhefferon plantderivedanticancertherapeuticsandbiopharmaceuticals AT afaghyavari plantderivedanticancertherapeuticsandbiopharmaceuticals AT srividhyavenkataraman plantderivedanticancertherapeuticsandbiopharmaceuticals |