Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare
Polyarteritis nodosa (PAN) is a systemic vasculitis whose severe forms are treated with glucocorticoids and cyclophosphamide. Refractory patients are exposed to many complications, notably accelerated atherosclerosis. We report a case report of 71-year-old man followed for polyarteritis nodosa refra...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/738293 |
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| author | Emmanuel Ribeiro Thomas Cressend Pierre Duffau Marieke Grenouillet-Delacre Marie Rouanet-Larivière Anne Vital Maïté Longy-Boursier Patrick Mercié |
| author_facet | Emmanuel Ribeiro Thomas Cressend Pierre Duffau Marieke Grenouillet-Delacre Marie Rouanet-Larivière Anne Vital Maïté Longy-Boursier Patrick Mercié |
| author_sort | Emmanuel Ribeiro |
| collection | DOAJ |
| description | Polyarteritis nodosa (PAN) is a systemic vasculitis whose severe forms are treated with glucocorticoids and cyclophosphamide. Refractory patients are exposed to many complications, notably accelerated atherosclerosis. We report a case report of 71-year-old man followed for polyarteritis nodosa refractory to glucocorticoids and cyclosphosphamide. Systemic vasculitis relapses are followed to accelerated atherosclerosis: severe ischemic lesions led to amputation of lower limbs. Remission of refractory PAN is obtained with rituximab. Disappearance of biological inflammatory is allowed to regression of ischemic lesions in upper limbs. In this situation, we recommend a systematic vascular work-up for patients suffered from refractory vasculitis. On the other hand, therapeutic trials are needed to determine the real efficacy and place of rituximab in the treatment of polyarteritis nodosa. |
| format | Article |
| id | doaj-art-7e916e7e3e13468f8440999a880a205e |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-7e916e7e3e13468f8440999a880a205e2025-02-03T01:21:31ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/738293738293Rituximab Efficacy during a Refractory Polyarteritis Nodosa FlareEmmanuel Ribeiro0Thomas Cressend1Pierre Duffau2Marieke Grenouillet-Delacre3Marie Rouanet-Larivière4Anne Vital5Maïté Longy-Boursier6Patrick Mercié7Service de Médecine Interne, Hôpital Saint-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, FranceService de Médecine Interne, Hôpital Saint-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, FranceService de Médecine Interne et Maladies Infectieuses, Hôpital Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac, FranceService de Médecine Interne, Hôpital Saint-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, FranceService d'Exploration Fonctionnelle du Système Nerveux, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, FranceLaboratoire d'Anatomo-Pathologie, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, FranceService de Médecine Interne, Hôpital Saint-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, FranceService de Médecine Interne, Hôpital Saint-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, FrancePolyarteritis nodosa (PAN) is a systemic vasculitis whose severe forms are treated with glucocorticoids and cyclophosphamide. Refractory patients are exposed to many complications, notably accelerated atherosclerosis. We report a case report of 71-year-old man followed for polyarteritis nodosa refractory to glucocorticoids and cyclosphosphamide. Systemic vasculitis relapses are followed to accelerated atherosclerosis: severe ischemic lesions led to amputation of lower limbs. Remission of refractory PAN is obtained with rituximab. Disappearance of biological inflammatory is allowed to regression of ischemic lesions in upper limbs. In this situation, we recommend a systematic vascular work-up for patients suffered from refractory vasculitis. On the other hand, therapeutic trials are needed to determine the real efficacy and place of rituximab in the treatment of polyarteritis nodosa.http://dx.doi.org/10.1155/2009/738293 |
| spellingShingle | Emmanuel Ribeiro Thomas Cressend Pierre Duffau Marieke Grenouillet-Delacre Marie Rouanet-Larivière Anne Vital Maïté Longy-Boursier Patrick Mercié Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare Case Reports in Medicine |
| title | Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare |
| title_full | Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare |
| title_fullStr | Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare |
| title_full_unstemmed | Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare |
| title_short | Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare |
| title_sort | rituximab efficacy during a refractory polyarteritis nodosa flare |
| url | http://dx.doi.org/10.1155/2009/738293 |
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