Knowledge, Attitudes, and Practices of the General Population Regarding Peripheral Blood Chromosomal Testing in the Premarital or Preconception Context
ABSTRACT Objectives Some previous studies examined the knowledge, attitudes, and practices (KAP) toward prenatal genetic testing of the fetus but not toward blood chromosomal testing in the preconception and premarital period. This study investigated the KAP of the general population regarding perip...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-05-01
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| Series: | Molecular Genetics & Genomic Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mgg3.70103 |
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| Summary: | ABSTRACT Objectives Some previous studies examined the knowledge, attitudes, and practices (KAP) toward prenatal genetic testing of the fetus but not toward blood chromosomal testing in the preconception and premarital period. This study investigated the KAP of the general population regarding peripheral blood chromosomal testing in the premarital or preconception period. Design A cross‐sectional study. Setting From October 2023 to December 2023 at the authors' hospital. Participants Enrolled individuals who participated in free premarital medical examinations and free prepregnancy health examinations. Primary and Secondary Outcome Measures A self‐designed questionnaire (Cronbach's α = 0.917) was used to collect the demographic information and KAP scores. KAP scores across variable categories were analyzed using the Mann–Whitney U test or Kruskal–Wallis H test. Correlations between KAP scores were evaluated by Pearson correlation analysis. Factors associated with KAP were identified by multivariable logistic regression. Results This study included 630 valid questionnaires. The mean knowledge, attitude, and practice scores were 18.90 ± 4.48 (/30, 63.00%), 40.99 ± 5.32 (/50, 81.98%), and 37.66 ± 4.43 (/45, 83.69%), respectively. The knowledge scores were similar between genders (p = 0.840). Compared with males, females had higher attitude scores (42.01 ± 5.40 vs. 40.01 ± 5.07, p < 0.001) and higher practice scores (38.17 ± 4.44 vs. 37.18 ± 4.37, p = 0.013). There were no significant differences between genders regarding the frequencies of having undergone chromosomal testing and recommending it to the partner. The knowledge scores (OR = 1.060, 95% CI: 1.018–1.103, p = 0.004) and attitude scores (OR = 1.198, 95% CI: 1.154–1.244, p < 0.001) were positively independently associated with the practice scores. Conclusions The general population in Hangzhou displays poor knowledge but favorable attitudes and proactive practices regarding peripheral blood chromosomal testing in the premarital or preconception period. Cultivating proper knowledge and attitude should improve practice. |
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| ISSN: | 2324-9269 |