Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays.

Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays.

Disease associated pathological aggregates of alpha-synuclein (αSynD) exhibit prion-like spreading in synucleinopathies such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Seed amplification assays (SAAs) such as real-time quaking-induced conversion (RT-QuIC) have shown high d...

Full description

Saved in:
Bibliographic Details
Main Authors: Ankit Srivastava, Qinlu Wang, Christina D Orrù, Manel Fernandez, Yaroslau Compta, Bernardino Ghetti, Gianluigi Zanusso, Wen-Quan Zou, Byron Caughey, Catherine A A Beauchemin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012554
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1371/journal.ppat.1012554

Similar Items