Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism
The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/6595740 |
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| author | Eriola Hoxha Pellegrino Lippiello Bibiana Scelfo Filippo Tempia Mirella Ghirardi Maria Concetta Miniaci |
| author_facet | Eriola Hoxha Pellegrino Lippiello Bibiana Scelfo Filippo Tempia Mirella Ghirardi Maria Concetta Miniaci |
| author_sort | Eriola Hoxha |
| collection | DOAJ |
| description | The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plasticity mechanisms underlying the formation of new synapses and retraction of redundant ones. For the attainment of the monoinnervation of the Purkinje cell by a single climbing fiber, several signals are involved, including electrical activity, contact signals, homosynaptic and heterosynaptic interaction, calcium transients, postsynaptic receptors, and transduction pathways. An important role in this developmental program is played by serotonergic projections that, acting on temporally and spatially regulated postsynaptic receptors, induce and modulate the phases of synaptic formation and maturation. In the adult cerebellar cortex, many developmental mechanisms persist but play different roles, such as supporting synaptic plasticity during learning and formation of cerebellar memory traces. A dysfunction at any stage of this process can lead to disorders of cerebellar origin, which include autism spectrum disorders but are not limited to motor deficits. Recent evidence in animal models links impairment of Purkinje cell function with autism-like symptoms including sociability deficits, stereotyped movements, and interspecific communication by vocalization. |
| format | Article |
| id | doaj-art-7e7b8169970246e495af5bf2b5b53592 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7e7b8169970246e495af5bf2b5b535922025-02-03T01:30:09ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/65957406595740Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of AutismEriola Hoxha0Pellegrino Lippiello1Bibiana Scelfo2Filippo Tempia3Mirella Ghirardi4Maria Concetta Miniaci5Neuroscience Institute Cavalieri Ottolenghi (NICO), Torino, ItalyDepartment of Pharmacy, University of Naples Federico II, Naples, ItalyDepartment of Neuroscience, University of Torino, Torino, ItalyNeuroscience Institute Cavalieri Ottolenghi (NICO), Torino, ItalyDepartment of Neuroscience, University of Torino, Torino, ItalyDepartment of Pharmacy, University of Naples Federico II, Naples, ItalyThe formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plasticity mechanisms underlying the formation of new synapses and retraction of redundant ones. For the attainment of the monoinnervation of the Purkinje cell by a single climbing fiber, several signals are involved, including electrical activity, contact signals, homosynaptic and heterosynaptic interaction, calcium transients, postsynaptic receptors, and transduction pathways. An important role in this developmental program is played by serotonergic projections that, acting on temporally and spatially regulated postsynaptic receptors, induce and modulate the phases of synaptic formation and maturation. In the adult cerebellar cortex, many developmental mechanisms persist but play different roles, such as supporting synaptic plasticity during learning and formation of cerebellar memory traces. A dysfunction at any stage of this process can lead to disorders of cerebellar origin, which include autism spectrum disorders but are not limited to motor deficits. Recent evidence in animal models links impairment of Purkinje cell function with autism-like symptoms including sociability deficits, stereotyped movements, and interspecific communication by vocalization.http://dx.doi.org/10.1155/2017/6595740 |
| spellingShingle | Eriola Hoxha Pellegrino Lippiello Bibiana Scelfo Filippo Tempia Mirella Ghirardi Maria Concetta Miniaci Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism Neural Plasticity |
| title | Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism |
| title_full | Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism |
| title_fullStr | Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism |
| title_full_unstemmed | Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism |
| title_short | Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism |
| title_sort | maturation refinement and serotonergic modulation of cerebellar cortical circuits in normal development and in murine models of autism |
| url | http://dx.doi.org/10.1155/2017/6595740 |
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