Multitarget mechanism of MYC inhibition by the bacterial lon protease in disease

Multitarget mechanism of MYC inhibition by the bacterial lon protease in disease

Abstract Identifying specific inhibitors of the MYC oncogene has been challenging, due to off target effects associated with MYC inhibition. This study investigated how the recombinant Escherichia coli Lon protease (rLon), which targets MYC in human cells, inhibits MYC over-activation in models of i...

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Main Authors: Ines Ambite, Murphy Lam Yim Wan, Hien Thi Tran, Atefeh Nazari, Arunima Chaudhuri, Christian Krintel, Inês Gomes, Samudra Sabari, Shahram Ahmadi, António N. B. M. Carneiro, Rita Ishac, Farhan Haq, Catharina Svanborg
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-88093-2
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