Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining
Oxidative stress, which results in an excessive product of reactive oxygen species (ROS), is one of the fundamental mechanisms of the development of hypertension. In the vascular system, ROS have physical and pathophysiological roles in vascular remodeling and endothelial dysfunction. In this study,...
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| Language: | English |
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BioMed Central
2012-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-10-244.pdf |
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| author | Ji Eun Lim Kyung-Won Hong Hyun-Seok Jin Bermseok Oh |
| author_facet | Ji Eun Lim Kyung-Won Hong Hyun-Seok Jin Bermseok Oh |
| author_sort | Ji Eun Lim |
| collection | DOAJ |
| description | Oxidative stress, which results in an excessive product of reactive oxygen species (ROS), is one of the fundamental mechanisms of the development of hypertension. In the vascular system, ROS have physical and pathophysiological roles in vascular remodeling and endothelial dysfunction. In this study, ROS-hypertension-related genes were collected by the biological literature-mining tools, such as SciMiner and gene2pubmed, in order to identify the genes that would cause hypertension through ROS. Further, single nucleotide polymorphisms (SNPs) located within these gene regions were examined statistically for their association with hypertension in 6,419 Korean individuals, and pathway enrichment analysis using the associated genes was performed. The 2,945 SNPs of 237 ROS-hypertension genes were analyzed, and 68 genes were significantly associated with hypertension (p < 0.05). The most significant SNP was rs2889611 within MAPK8 (p = 2.70 × 10-5; odds ratio, 0.82; confidence interval, 0.75 to 0.90). This study demonstrates that a text mining approach combined with association analysis may be useful to identify the candidate genes that cause hypertension through ROS or oxidative stress. |
| format | Article |
| id | doaj-art-7e637b7dc1884200a680bb58051cc702 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2012-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-7e637b7dc1884200a680bb58051cc7022025-02-02T11:40:42ZengBioMed CentralGenomics & Informatics1598-866X2234-07422012-12-0110424424810.5808/GI.2012.10.4.24422Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature MiningJi Eun Lim0Kyung-Won Hong1Hyun-Seok Jin2Bermseok Oh3Department of Biomedical Engineering, Kyung Hee University School of Medicine, Seoul 130-701, Korea.Division of Epidemiology and Health Index, Center for Genome Science, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongwon 363-951, Korea.Department of Medical Genetics, Ajou University School of Medicine, Suwon 443-721, Korea.Department of Biomedical Engineering, Kyung Hee University School of Medicine, Seoul 130-701, Korea.Oxidative stress, which results in an excessive product of reactive oxygen species (ROS), is one of the fundamental mechanisms of the development of hypertension. In the vascular system, ROS have physical and pathophysiological roles in vascular remodeling and endothelial dysfunction. In this study, ROS-hypertension-related genes were collected by the biological literature-mining tools, such as SciMiner and gene2pubmed, in order to identify the genes that would cause hypertension through ROS. Further, single nucleotide polymorphisms (SNPs) located within these gene regions were examined statistically for their association with hypertension in 6,419 Korean individuals, and pathway enrichment analysis using the associated genes was performed. The 2,945 SNPs of 237 ROS-hypertension genes were analyzed, and 68 genes were significantly associated with hypertension (p < 0.05). The most significant SNP was rs2889611 within MAPK8 (p = 2.70 × 10-5; odds ratio, 0.82; confidence interval, 0.75 to 0.90). This study demonstrates that a text mining approach combined with association analysis may be useful to identify the candidate genes that cause hypertension through ROS or oxidative stress.http://genominfo.org/upload/pdf/gni-10-244.pdfgenetic association studyhypertensionliterature miningreactive oxygen species |
| spellingShingle | Ji Eun Lim Kyung-Won Hong Hyun-Seok Jin Bermseok Oh Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining Genomics & Informatics genetic association study hypertension literature mining reactive oxygen species |
| title | Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining |
| title_full | Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining |
| title_fullStr | Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining |
| title_full_unstemmed | Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining |
| title_short | Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining |
| title_sort | association analysis of reactive oxygen species hypertension genes discovered by literature mining |
| topic | genetic association study hypertension literature mining reactive oxygen species |
| url | http://genominfo.org/upload/pdf/gni-10-244.pdf |
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