A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review
Abstract Palmitoylethanolamide (PEA) has been prescribed in neuropathic pain management for over 20 years. This study aims to summarize what has been published on the topic in the last 15 years and determine the appropriateness of the prescribing. It describes the pharmacological aspect of PEA, espe...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-12-01
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| Series: | Pain and Therapy |
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| Online Access: | https://doi.org/10.1007/s40122-024-00685-4 |
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| author | Giustino Varrassi Martina Rekatsina Matteo Luigi Giuseppe Leoni Marco Cascella Gabriele Finco Salvatore Sardo Chiara Corno Domenico Tiso Vittorio Schweiger Diego Maria Michele Fornasari Antonella Paladini |
| author_facet | Giustino Varrassi Martina Rekatsina Matteo Luigi Giuseppe Leoni Marco Cascella Gabriele Finco Salvatore Sardo Chiara Corno Domenico Tiso Vittorio Schweiger Diego Maria Michele Fornasari Antonella Paladini |
| author_sort | Giustino Varrassi |
| collection | DOAJ |
| description | Abstract Palmitoylethanolamide (PEA) has been prescribed in neuropathic pain management for over 20 years. This study aims to summarize what has been published on the topic in the last 15 years and determine the appropriateness of the prescribing. It describes the pharmacological aspect of PEA, especially focusing on its pharmacodynamics and pharmacokinetics. Then, it deeply explores why PEA may be useful in the pharmacological management of both neuropathic and mixed pain. Finally, it examines some innovative patent, which aims to address obstacles encountered with conventional PEA formulations, for its pharmacodynamic characteristics. One of them (Equisetum-PEA) seems promising. It partially ameliorates the bioavailability and the targeted distribution. It seems to introduce novel advancements that can potentially enhance the therapeutic effectiveness of PEA in terms of its anti-inflammatory, antioxidant, and analgesic properties. The deep literature analysis aims to examine the potential advantages of PEA, in the context of several pathological conditions that may benefit from this molecule. It focuses on various published data regarding the clinical efficacy of PEA in managing neuropathic and mixed pain. Also, it tries to understand if it can modernize the field of therapy based on PEA, thus offering a better treatment option for individuals with chronic long-term inflammation, oxidative stress, and neuropathic or mixed pain with a neuropathic component. The study examines the possible impact of PEA on personalized medicine strategies and its potential for translation into clinical practice. It analyses the possibilities that PEA has in enhancing patient outcomes in a range of central nervous system and inflammatory conditions. A complete analysis of the therapeutic potentialities of this product was missing. This extensive narrative review makes a valuable contribution to the ongoing comprehension of PEA therapy. It establishes a foundation for further exploration in research and potential uses in clinical settings. |
| format | Article |
| id | doaj-art-7e5a4b4c775448289c16df861295541e |
| institution | Kabale University |
| issn | 2193-8237 2193-651X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Pain and Therapy |
| spelling | doaj-art-7e5a4b4c775448289c16df861295541e2025-01-26T12:14:05ZengAdis, Springer HealthcarePain and Therapy2193-82372193-651X2024-12-011418110110.1007/s40122-024-00685-4A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative ReviewGiustino Varrassi0Martina Rekatsina1Matteo Luigi Giuseppe Leoni2Marco Cascella3Gabriele Finco4Salvatore Sardo5Chiara Corno6Domenico Tiso7Vittorio Schweiger8Diego Maria Michele Fornasari9Antonella Paladini10Fondazione Paolo ProcacciDepartment of Anesthesia and Pain Management, National and Kapodistrian University of AthensDepartment of Medical and Surgical Sciences and Translational Medicine, Sapienza University of RomaAnesthesia and Pain Medicine, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of SalernoDepartment of Medical Sciences and Public Health, Università di CagliariDepartment of Medical Sciences and Public Health, Università di CagliariURGO FoundationDepartment of Nutrition, “Villa Maria” HospitalDepartment of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB RossiDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di MilanoDepartment of Life, Health, and Environmental Sciences, Università degli Studi dell’AquilaAbstract Palmitoylethanolamide (PEA) has been prescribed in neuropathic pain management for over 20 years. This study aims to summarize what has been published on the topic in the last 15 years and determine the appropriateness of the prescribing. It describes the pharmacological aspect of PEA, especially focusing on its pharmacodynamics and pharmacokinetics. Then, it deeply explores why PEA may be useful in the pharmacological management of both neuropathic and mixed pain. Finally, it examines some innovative patent, which aims to address obstacles encountered with conventional PEA formulations, for its pharmacodynamic characteristics. One of them (Equisetum-PEA) seems promising. It partially ameliorates the bioavailability and the targeted distribution. It seems to introduce novel advancements that can potentially enhance the therapeutic effectiveness of PEA in terms of its anti-inflammatory, antioxidant, and analgesic properties. The deep literature analysis aims to examine the potential advantages of PEA, in the context of several pathological conditions that may benefit from this molecule. It focuses on various published data regarding the clinical efficacy of PEA in managing neuropathic and mixed pain. Also, it tries to understand if it can modernize the field of therapy based on PEA, thus offering a better treatment option for individuals with chronic long-term inflammation, oxidative stress, and neuropathic or mixed pain with a neuropathic component. The study examines the possible impact of PEA on personalized medicine strategies and its potential for translation into clinical practice. It analyses the possibilities that PEA has in enhancing patient outcomes in a range of central nervous system and inflammatory conditions. A complete analysis of the therapeutic potentialities of this product was missing. This extensive narrative review makes a valuable contribution to the ongoing comprehension of PEA therapy. It establishes a foundation for further exploration in research and potential uses in clinical settings.https://doi.org/10.1007/s40122-024-00685-4Degenerative neuropathiesPainNeuropathic painMixed painPalmitoylethanolamide (PEA)EquiPEA® |
| spellingShingle | Giustino Varrassi Martina Rekatsina Matteo Luigi Giuseppe Leoni Marco Cascella Gabriele Finco Salvatore Sardo Chiara Corno Domenico Tiso Vittorio Schweiger Diego Maria Michele Fornasari Antonella Paladini A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review Pain and Therapy Degenerative neuropathies Pain Neuropathic pain Mixed pain Palmitoylethanolamide (PEA) EquiPEA® |
| title | A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review |
| title_full | A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review |
| title_fullStr | A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review |
| title_full_unstemmed | A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review |
| title_short | A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review |
| title_sort | decades long journey of palmitoylethanolamide pea for chronic neuropathic pain management a comprehensive narrative review |
| topic | Degenerative neuropathies Pain Neuropathic pain Mixed pain Palmitoylethanolamide (PEA) EquiPEA® |
| url | https://doi.org/10.1007/s40122-024-00685-4 |
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