Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives
Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between α-haloketone and thioamide, and their Zn(II) complexes were prep...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2020/8852470 |
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| author | Zou Xun-Zhong Feng An-Sheng Zeng Fu-Ran Lai Min-Cheng Liao Yan-Zhi Mei Meng Li Yu |
| author_facet | Zou Xun-Zhong Feng An-Sheng Zeng Fu-Ran Lai Min-Cheng Liao Yan-Zhi Mei Meng Li Yu |
| author_sort | Zou Xun-Zhong |
| collection | DOAJ |
| description | Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between α-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in a monoclinic system. The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines. |
| format | Article |
| id | doaj-art-7e5702cbf35d445e82a25fac01f6a162 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-7e5702cbf35d445e82a25fac01f6a1622025-02-03T06:46:35ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2020-01-01202010.1155/2020/88524708852470Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole DerivativesZou Xun-Zhong0Feng An-Sheng1Zeng Fu-Ran2Lai Min-Cheng3Liao Yan-Zhi4Mei Meng5Li Yu6Guangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, ChinaGuangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, ChinaGuangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, ChinaGuangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, ChinaGuangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, ChinaWuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430015, ChinaGuangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, ChinaTwo pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between α-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in a monoclinic system. The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.http://dx.doi.org/10.1155/2020/8852470 |
| spellingShingle | Zou Xun-Zhong Feng An-Sheng Zeng Fu-Ran Lai Min-Cheng Liao Yan-Zhi Mei Meng Li Yu Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives Bioinorganic Chemistry and Applications |
| title | Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives |
| title_full | Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives |
| title_fullStr | Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives |
| title_full_unstemmed | Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives |
| title_short | Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives |
| title_sort | synthesis crystal structures and antimicrobial and antitumor studies of two zinc ii complexes with pyridine thiazole derivatives |
| url | http://dx.doi.org/10.1155/2020/8852470 |
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