Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics

Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics

IntroductionDepressive/anxiety symptoms are common in subjective cognitive decline (SCD) and may relate to Alzheimer’s pathology, potentially modulated by personality characteristics.MethodsDepressive/anxiety symptoms were assessed over 4 ± 2 years in 329 SCD (88 amyloid-positive/241 amyloid-negativ...

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Main Authors: Calvin Trieu, Mardou S. S. A. van Leeuwenstijn, Lisa-Marie Schlüter, Jarith L. Ebenau, Inge M. W. Verberk, Sietske A. M. Sikkes, Sander C. J. Verfaillie, Elsmarieke van de Giessen, Charlotte E. Teunissen, Wiesje M. van der Flier, Argonde C. van Harten
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Psychiatry
Subjects:
Alzheimer’s disease
depression
anxiety
subjective cognitive decline
neuroticism
somatization
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1572174/full
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Summary:IntroductionDepressive/anxiety symptoms are common in subjective cognitive decline (SCD) and may relate to Alzheimer’s pathology, potentially modulated by personality characteristics.MethodsDepressive/anxiety symptoms were assessed over 4 ± 2 years in 329 SCD (88 amyloid-positive/241 amyloid-negative) using Geriatric Depression Scale-15 (GDS), Center for Epidemiological Studies-Depression (CES-D), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Mixed-effects models assessed associations between amyloid status and these symptoms, with neuroticism and somatization as effect-modifiers.ResultsAmyloid status was not directly associated with GDS, CES-D or HADS-A. However, neuroticism modified the association between amyloid status and GDS (p<0.05). In lower neuroticism, amyloid positivity was associated with GDS increase (β:0.10 ± 0.08), but not in higher neuroticism (β:-0.04 ± 0.12). Somatization modified the association between amyloid status and CES-D (p<0.05). In lower somatization, amyloid positivity was associated with CES-D increase (β:0.65 ± 0.23), but not in higher somatization (β:-0.12 ± 0.29).DiscussionAmyloid-positive individuals with lower neuroticism/somatization increased more in depressive symptoms over time, suggesting a preclinical AD-related depressive phenotype.
ISSN:1664-0640

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