Developing safe and efficient CGBE editor based on Cas-embedding strategy

Developing safe and efficient CGBE editor based on Cas-embedding strategy

CGBE (C-to-G base editor) systems, pivotal components within the base editing arsenal, enable the precise conversion of cytosines to guanines. However, conventional cytidine deaminases possess non-specific single-stranded DNA binding properties, leading to off-target effects and safety concerns. The...

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Bibliographic Details
Main Authors: Tian Lin, Xin Wang, Yu Zhang, Guanglei Li, Xingxu Huang, Ming Shi
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-06-01
Series:Synthetic and Systems Biotechnology
Subjects:
CGBE
Cas-embedding
Off-target
eA3A
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X25000092
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