Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease
Dry eye disease (DED) is the most common ocular disease and affects millions of individuals worldwide. DED encompasses a heterogeneous group of diseases that can be generally divided into two forms including aqueous-deficient and evaporative DED. Evidence suggests that these conditions arise from ei...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/2532314 |
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| author | José L. Reyes Danielle T. Vannan Bertus Eksteen Imelda Juárez Avelar Tonathiu Rodríguez Marisol Ibet González Alicia Vázquez Mendoza |
| author_facet | José L. Reyes Danielle T. Vannan Bertus Eksteen Imelda Juárez Avelar Tonathiu Rodríguez Marisol Ibet González Alicia Vázquez Mendoza |
| author_sort | José L. Reyes |
| collection | DOAJ |
| description | Dry eye disease (DED) is the most common ocular disease and affects millions of individuals worldwide. DED encompasses a heterogeneous group of diseases that can be generally divided into two forms including aqueous-deficient and evaporative DED. Evidence suggests that these conditions arise from either failure of lacrimal gland secretion or low tear film quality. In its secondary form, DED is often associated with autoimmune diseases such as Sjögren’s syndrome and rheumatoid arthritis. Current treatment strategies for DED are limited to anti-inflammatory medications that target the immune system as the source of deleterious inflammation and tissue injury. However, there is a lack of understanding of the underlying pathogenesis of DED, and subsequently, there are very few effective treatment strategies. The gap in our knowledge of the etiology of primary DED is in part because the majority of research in DED focused on secondary autoimmune causes. This review focuses on what is currently understood about the contribution of innate and adaptive immune cell populations in the pathogenesis of DED and highlights the need to continue investigating the central role of immunity driving DED. |
| format | Article |
| id | doaj-art-7e44c1767af049b1a70e58a4b7577793 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7e44c1767af049b1a70e58a4b75777932025-02-03T05:53:32ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/25323142532314Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye DiseaseJosé L. Reyes0Danielle T. Vannan1Bertus Eksteen2Imelda Juárez Avelar3Tonathiu Rodríguez4Marisol Ibet González5Alicia Vázquez Mendoza6Universidad Nacional Autónoma de México (UNAM), Laboratorio de Inmunología experimental y Regulación de la inflamación Hepato-Intestinal, UBIMED, Facultad de Estudios Superiores (FES) Iztacala, Tlalnepantla, MEX, MexicoUniversity of Calgary, Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary, AB, CanadaAspen Woods Clinic, Calgary, AB, CanadaUniversidad Nacional Autónoma de México (UNAM), Unidad de Biomedicina (UBIMED), Facultad de Estudios Superiores (FES) Iztacala, Tlalnepantla, MEX, MexicoUniversidad Nacional Autónoma de México (UNAM), Unidad de Biomedicina (UBIMED), Facultad de Estudios Superiores (FES) Iztacala, Tlalnepantla, MEX, MexicoUniversidad Nacional Autónoma de México (UNAM), Laboratorio de Inmunología experimental y Regulación de la inflamación Hepato-Intestinal, UBIMED, Facultad de Estudios Superiores (FES) Iztacala, Tlalnepantla, MEX, MexicoUniversidad Nacional Autónoma de México (UNAM), Laboratorio de Enfermedades Inflamatorias Oculares, Carrera de Optometría, Facultad de Estudios Superiores (FES) Iztacala, Tlalnepantla, MEX, MexicoDry eye disease (DED) is the most common ocular disease and affects millions of individuals worldwide. DED encompasses a heterogeneous group of diseases that can be generally divided into two forms including aqueous-deficient and evaporative DED. Evidence suggests that these conditions arise from either failure of lacrimal gland secretion or low tear film quality. In its secondary form, DED is often associated with autoimmune diseases such as Sjögren’s syndrome and rheumatoid arthritis. Current treatment strategies for DED are limited to anti-inflammatory medications that target the immune system as the source of deleterious inflammation and tissue injury. However, there is a lack of understanding of the underlying pathogenesis of DED, and subsequently, there are very few effective treatment strategies. The gap in our knowledge of the etiology of primary DED is in part because the majority of research in DED focused on secondary autoimmune causes. This review focuses on what is currently understood about the contribution of innate and adaptive immune cell populations in the pathogenesis of DED and highlights the need to continue investigating the central role of immunity driving DED.http://dx.doi.org/10.1155/2018/2532314 |
| spellingShingle | José L. Reyes Danielle T. Vannan Bertus Eksteen Imelda Juárez Avelar Tonathiu Rodríguez Marisol Ibet González Alicia Vázquez Mendoza Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease Mediators of Inflammation |
| title | Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease |
| title_full | Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease |
| title_fullStr | Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease |
| title_full_unstemmed | Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease |
| title_short | Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease |
| title_sort | innate and adaptive cell populations driving inflammation in dry eye disease |
| url | http://dx.doi.org/10.1155/2018/2532314 |
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