Global, regional, and national burden of disease analysis on paralytic ileus and intestinal obstruction in adults aged 65 and over from 1990 to 2021, with projections for 2030: a Global Burden of Disease Study 2021 analysis
Abstract Objective This study aimed to evaluate the burden and trends of paralytic ileus and bowel obstruction in individuals aged ≥ 65 years, offering insights into prevention, treatment, and healthcare policy. Methods Data from the Global Burden of Disease Study 2021 were used to analyze paralytic...
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BMC
2025-04-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03904-0 |
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| author | Tao Zhang Meng Chen Zhitong Yu Zhetan Ren Ling Wang Qi Si Xinping Lu Siyuan Bu Sihong Shen Qingyan Wang Yongduo Yu |
| author_facet | Tao Zhang Meng Chen Zhitong Yu Zhetan Ren Ling Wang Qi Si Xinping Lu Siyuan Bu Sihong Shen Qingyan Wang Yongduo Yu |
| author_sort | Tao Zhang |
| collection | DOAJ |
| description | Abstract Objective This study aimed to evaluate the burden and trends of paralytic ileus and bowel obstruction in individuals aged ≥ 65 years, offering insights into prevention, treatment, and healthcare policy. Methods Data from the Global Burden of Disease Study 2021 were used to analyze paralytic ileus and intestinal obstruction by demographics, year, country/region, and Socio-Demographic Index (SDI). The statistical methods included Joinpoint regression, decomposition analysis, and Bayesian Age-Period-Cohort modeling. Results In 2021, the global age-standardized incidence of paralytic ileus and intestinal obstruction among the elderly was 643.45 cases per 100,000 individuals. The corresponding prevalence was 24.05 per 100,000 individuals, with disability-adjusted life years (DALYs) of 294.01 per 100,000 person-years and a mortality rate of 20.55 per 100,000 individuals. Between 1990 and 2021, the age-standardized incidence and prevalence of paralytic ileus and intestinal obstruction in the elderly gradually increased, while age-standardized DALYs and mortality consistently declined. Despite similar trends observed across both genders, the disease burden increased with age and was more pronounced in males than in females. Furthermore, the age-standardized incidence and prevalence of these conditions increased with SDI, whereas mortality and DALYs decreased. By 2030, the incidence and prevalence are expected to continue increasing, whereas mortality and DALYs are expected to decrease. Conclusions Despite the consistent decrease in mortality and DALYs associated with paralytic ileus and bowel obstruction in the elderly population aged ≥ 65 years, their incidence and prevalence continue to increase annually. This underscores the importance of improving preventive measures, early screening, and treatment efforts to address this pressing public health challenge. |
| format | Article |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-7e3cc68a7b4b44ac9dde7cff8f4c6bc02025-08-20T02:19:58ZengBMCBMC Gastroenterology1471-230X2025-04-0125111510.1186/s12876-025-03904-0Global, regional, and national burden of disease analysis on paralytic ileus and intestinal obstruction in adults aged 65 and over from 1990 to 2021, with projections for 2030: a Global Burden of Disease Study 2021 analysisTao Zhang0Meng Chen1Zhitong Yu2Zhetan Ren3Ling Wang4Qi Si5Xinping Lu6Siyuan Bu7Sihong Shen8Qingyan Wang9Yongduo Yu10Liaoning University of Traditional Chinese MedicineThird Affiliated Hospital, Liaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical UniversityLiaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineSecond Affiliated Hospital, Liaoning University of Traditional Chinese MedicineAbstract Objective This study aimed to evaluate the burden and trends of paralytic ileus and bowel obstruction in individuals aged ≥ 65 years, offering insights into prevention, treatment, and healthcare policy. Methods Data from the Global Burden of Disease Study 2021 were used to analyze paralytic ileus and intestinal obstruction by demographics, year, country/region, and Socio-Demographic Index (SDI). The statistical methods included Joinpoint regression, decomposition analysis, and Bayesian Age-Period-Cohort modeling. Results In 2021, the global age-standardized incidence of paralytic ileus and intestinal obstruction among the elderly was 643.45 cases per 100,000 individuals. The corresponding prevalence was 24.05 per 100,000 individuals, with disability-adjusted life years (DALYs) of 294.01 per 100,000 person-years and a mortality rate of 20.55 per 100,000 individuals. Between 1990 and 2021, the age-standardized incidence and prevalence of paralytic ileus and intestinal obstruction in the elderly gradually increased, while age-standardized DALYs and mortality consistently declined. Despite similar trends observed across both genders, the disease burden increased with age and was more pronounced in males than in females. Furthermore, the age-standardized incidence and prevalence of these conditions increased with SDI, whereas mortality and DALYs decreased. By 2030, the incidence and prevalence are expected to continue increasing, whereas mortality and DALYs are expected to decrease. Conclusions Despite the consistent decrease in mortality and DALYs associated with paralytic ileus and bowel obstruction in the elderly population aged ≥ 65 years, their incidence and prevalence continue to increase annually. This underscores the importance of improving preventive measures, early screening, and treatment efforts to address this pressing public health challenge.https://doi.org/10.1186/s12876-025-03904-0Paralytic ileus and intestinal obstructionOlder adultsDisease burdenTrend analysisProjections |
| spellingShingle | Tao Zhang Meng Chen Zhitong Yu Zhetan Ren Ling Wang Qi Si Xinping Lu Siyuan Bu Sihong Shen Qingyan Wang Yongduo Yu Global, regional, and national burden of disease analysis on paralytic ileus and intestinal obstruction in adults aged 65 and over from 1990 to 2021, with projections for 2030: a Global Burden of Disease Study 2021 analysis BMC Gastroenterology Paralytic ileus and intestinal obstruction Older adults Disease burden Trend analysis Projections |
| title | Global, regional, and national burden of disease analysis on paralytic ileus and intestinal obstruction in adults aged 65 and over from 1990 to 2021, with projections for 2030: a Global Burden of Disease Study 2021 analysis |
| title_full | Global, regional, and national burden of disease analysis on paralytic ileus and intestinal obstruction in adults aged 65 and over from 1990 to 2021, with projections for 2030: a Global Burden of Disease Study 2021 analysis |
| title_fullStr | Global, regional, and national burden of disease analysis on paralytic ileus and intestinal obstruction in adults aged 65 and over from 1990 to 2021, with projections for 2030: a Global Burden of Disease Study 2021 analysis |
| title_full_unstemmed | Global, regional, and national burden of disease analysis on paralytic ileus and intestinal obstruction in adults aged 65 and over from 1990 to 2021, with projections for 2030: a Global Burden of Disease Study 2021 analysis |
| title_short | Global, regional, and national burden of disease analysis on paralytic ileus and intestinal obstruction in adults aged 65 and over from 1990 to 2021, with projections for 2030: a Global Burden of Disease Study 2021 analysis |
| title_sort | global regional and national burden of disease analysis on paralytic ileus and intestinal obstruction in adults aged 65 and over from 1990 to 2021 with projections for 2030 a global burden of disease study 2021 analysis |
| topic | Paralytic ileus and intestinal obstruction Older adults Disease burden Trend analysis Projections |
| url | https://doi.org/10.1186/s12876-025-03904-0 |
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