Experimental Closed-Loop Control of Breast Cancer in Mice
Cancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer. The optimized therapeutic protocol is calculated in a closed-loop manner at fixed time in...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Complexity |
| Online Access: | http://dx.doi.org/10.1155/2022/9348166 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553611910971392 |
|---|---|
| author | Levente Kovács Bence Czakó Máté Siket Tamás Ferenci András Füredi Balázs Gombos Gergely Szakács Dániel András Drexler |
| author_facet | Levente Kovács Bence Czakó Máté Siket Tamás Ferenci András Füredi Balázs Gombos Gergely Szakács Dániel András Drexler |
| author_sort | Levente Kovács |
| collection | DOAJ |
| description | Cancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer. The optimized therapeutic protocol is calculated in a closed-loop manner at fixed time instants, twice in a week. The controller consists of a nonlinear model predictive controller which uses the state estimation of a moving horizon estimator. The estimator also computes parameter estimates of the prediction model such that the time varying nature of tumor evolution can be captured. Results show that remission can be induced in a 28-day interval using the algorithm. |
| format | Article |
| id | doaj-art-7e320d81c11d466f98a07cf862eb8391 |
| institution | Kabale University |
| issn | 1099-0526 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Complexity |
| spelling | doaj-art-7e320d81c11d466f98a07cf862eb83912025-02-03T05:53:34ZengWileyComplexity1099-05262022-01-01202210.1155/2022/9348166Experimental Closed-Loop Control of Breast Cancer in MiceLevente Kovács0Bence Czakó1Máté Siket2Tamás Ferenci3András Füredi4Balázs Gombos5Gergely Szakács6Dániel András Drexler7Physiological Controls Research CenterPhysiological Controls Research CenterPhysiological Controls Research CenterPhysiological Controls Research CenterDrug Resistance Research GroupDrug Resistance Research GroupDrug Resistance Research GroupPhysiological Controls Research CenterCancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer. The optimized therapeutic protocol is calculated in a closed-loop manner at fixed time instants, twice in a week. The controller consists of a nonlinear model predictive controller which uses the state estimation of a moving horizon estimator. The estimator also computes parameter estimates of the prediction model such that the time varying nature of tumor evolution can be captured. Results show that remission can be induced in a 28-day interval using the algorithm.http://dx.doi.org/10.1155/2022/9348166 |
| spellingShingle | Levente Kovács Bence Czakó Máté Siket Tamás Ferenci András Füredi Balázs Gombos Gergely Szakács Dániel András Drexler Experimental Closed-Loop Control of Breast Cancer in Mice Complexity |
| title | Experimental Closed-Loop Control of Breast Cancer in Mice |
| title_full | Experimental Closed-Loop Control of Breast Cancer in Mice |
| title_fullStr | Experimental Closed-Loop Control of Breast Cancer in Mice |
| title_full_unstemmed | Experimental Closed-Loop Control of Breast Cancer in Mice |
| title_short | Experimental Closed-Loop Control of Breast Cancer in Mice |
| title_sort | experimental closed loop control of breast cancer in mice |
| url | http://dx.doi.org/10.1155/2022/9348166 |
| work_keys_str_mv | AT leventekovacs experimentalclosedloopcontrolofbreastcancerinmice AT benceczako experimentalclosedloopcontrolofbreastcancerinmice AT matesiket experimentalclosedloopcontrolofbreastcancerinmice AT tamasferenci experimentalclosedloopcontrolofbreastcancerinmice AT andrasfuredi experimentalclosedloopcontrolofbreastcancerinmice AT balazsgombos experimentalclosedloopcontrolofbreastcancerinmice AT gergelyszakacs experimentalclosedloopcontrolofbreastcancerinmice AT danielandrasdrexler experimentalclosedloopcontrolofbreastcancerinmice |