Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender
Maternal exercise during pregnancy has been suggested to exert beneficial effects on brain functions of the offspring. Leptin is an adipocytokine which is secreted from adipose tissues and has positive effects on learning, memory, and synaptic plasticity. In this study, pregnant rats were moderately...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/429803 |
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| author | Ayfer Dayi Sinem Agilkaya Seda Ozbal Ferihan Cetin Ilkay Aksu Celal Gencoglu Sultan Cingoz Cetın Pekcetin Kazim Tugyan Berkant Muammer Kayatekin Nazan Uysal |
| author_facet | Ayfer Dayi Sinem Agilkaya Seda Ozbal Ferihan Cetin Ilkay Aksu Celal Gencoglu Sultan Cingoz Cetın Pekcetin Kazim Tugyan Berkant Muammer Kayatekin Nazan Uysal |
| author_sort | Ayfer Dayi |
| collection | DOAJ |
| description | Maternal exercise during pregnancy has been suggested to exert beneficial effects on brain functions of the offspring. Leptin is an adipocytokine which is secreted from adipose tissues and has positive effects on learning, memory, and synaptic plasticity. In this study, pregnant rats were moderately exercised and we observed the effects of this aerobic exercise on their prepubertal and adult offsprings' spatial learning, hippocampal neurogenesis, and expression of leptin. All the pups whose mothers exercised during pregnancy learned the platform earlier and spent longer time in the target quadrant. Their thigmotaxis times were shorter than those measured in the control group. It is shown that hippocampal CA1, CA3 neuron numbers increased in both prepubertal and adult pups, in addition that GD neuron numbers increased in adult pups. Leptin receptor expression significantly increased in the prepubertal male, adult male, and adult female pups. In our study, maternal running during pregnancy resulted in significant increase in the expression of leptin receptor but not in prepubertal female pups, enhanced hippocampal cell survival, and improved learning memory capability in prepubertal and adult rat pups, as compared to the control group. In conclusion, maternal exercise during pregnancy may regulate spatial plasticity in the hippocampus of the offspring by increasing the expression of leptin. |
| format | Article |
| id | doaj-art-7e2e0d8082b84e2e806e06e46b9c985b |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7e2e0d8082b84e2e806e06e46b9c985b2025-02-03T01:31:25ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/429803429803Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on GenderAyfer Dayi0Sinem Agilkaya1Seda Ozbal2Ferihan Cetin3Ilkay Aksu4Celal Gencoglu5Sultan Cingoz6Cetın Pekcetin7Kazim Tugyan8Berkant Muammer Kayatekin9Nazan Uysal10Department of Physiology, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Medical Biology and Genetics, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Histology and Embriology, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Physiology, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Physiology, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Physiology, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Medical Biology and Genetics, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Histology and Embriology, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Histology and Embriology, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Physiology, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Physiology, School of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyMaternal exercise during pregnancy has been suggested to exert beneficial effects on brain functions of the offspring. Leptin is an adipocytokine which is secreted from adipose tissues and has positive effects on learning, memory, and synaptic plasticity. In this study, pregnant rats were moderately exercised and we observed the effects of this aerobic exercise on their prepubertal and adult offsprings' spatial learning, hippocampal neurogenesis, and expression of leptin. All the pups whose mothers exercised during pregnancy learned the platform earlier and spent longer time in the target quadrant. Their thigmotaxis times were shorter than those measured in the control group. It is shown that hippocampal CA1, CA3 neuron numbers increased in both prepubertal and adult pups, in addition that GD neuron numbers increased in adult pups. Leptin receptor expression significantly increased in the prepubertal male, adult male, and adult female pups. In our study, maternal running during pregnancy resulted in significant increase in the expression of leptin receptor but not in prepubertal female pups, enhanced hippocampal cell survival, and improved learning memory capability in prepubertal and adult rat pups, as compared to the control group. In conclusion, maternal exercise during pregnancy may regulate spatial plasticity in the hippocampus of the offspring by increasing the expression of leptin.http://dx.doi.org/10.1100/2012/429803 |
| spellingShingle | Ayfer Dayi Sinem Agilkaya Seda Ozbal Ferihan Cetin Ilkay Aksu Celal Gencoglu Sultan Cingoz Cetın Pekcetin Kazim Tugyan Berkant Muammer Kayatekin Nazan Uysal Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender The Scientific World Journal |
| title | Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender |
| title_full | Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender |
| title_fullStr | Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender |
| title_full_unstemmed | Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender |
| title_short | Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender |
| title_sort | maternal aerobic exercise during pregnancy can increase spatial learning by affecting leptin expression on offspring s early and late period in life depending on gender |
| url | http://dx.doi.org/10.1100/2012/429803 |
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