Administration of antigenically distinct influenza viral particle combinations as an influenza vaccine strategy.

One approach for developing a more universal influenza vaccine is to elicit strong immune responses against canonically immunosubdominant epitopes in the surface exposed viral glycoproteins. While standard vaccines typically induce responses directed primarily against mutable epitopes in the hemaggl...

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Bibliographic Details
Main Authors: Xinyu Zhu, Zhaochen Luo, Rebecca A Leonard, Cait E Hamele, Rachel L Spreng, Nicholas S Heaton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012878
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