The effect of inflammatory bowel diseases on the risk of atherosclerosis: assessment according to ultrasound imaging and sphygmometry
Aim. To evaluate the effect of inflammatory bowel disease (IBD) on the risk of atherosclerosis in patients without known cardiovascular disease. Materials and methods. The study included 115 patients divided into three groups: 37 patients with Crohn's disease (CD), 44 with ulcerative colitis...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2025-01-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/637243/175189 |
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| Summary: | Aim. To evaluate the effect of inflammatory bowel disease (IBD) on the risk of atherosclerosis in patients without known cardiovascular disease.
Materials and methods. The study included 115 patients divided into three groups: 37 patients with Crohn's disease (CD), 44 with ulcerative colitis (UC), and 34 in the control group without known IBD and other risk factors. Doppler ultrasound of the brachiocephalic arteries and sphygmometry were used for diagnosis. The main indicators were the thickness of the intima-media complex (TIMC) and vascular stiffness, measured by the cardio-ankle vascular index (CAVI) and the ankle-brachial pressure index (ABI).
Results. IBD patients showed an increase in TIMC compared to controls. TIMC of the common carotid arteries on the right: in patients with CD – 0.07 cm (p=0.001), with UC – 0.08 cm (p=0.019), in the control group – 0.06 cm. TIMC of the common carotid arteries on the left: in patients with CD – 0.07 cm (p=0.001), with UC – 0.07 cm (p=0.012), in the control group – 0.06 cm. The sphygmometry indicators (CAVI and ABI) did not differ significantly between the groups. The mean CAVI on the right was 6.8±0.98 for the CD group, 6.6±0.79 for the UC group, and 6.82±0.76 for the control group (p=0.692).
Conclusion. IBD can contribute to the thickening of the vascular walls, thus increasing the risk of atherosclerosis, as shown by TIMC. Vascular stiffness indicators (CAVI, ABI) did not differ significantly between the groups. |
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| ISSN: | 0040-3660 2309-5342 |