Receptor Tyrosine Kinases and Inhibitors in Lung Cancer
Lung cancer is a deadly disease with high mortality and morbidity. Most cases of lung cancer are due to non-small cell carcinoma, with 16% of cases being small cell carcinoma. The biology at a cellular level is of interest at many levels. Knowing cellular pathways helps to further enhance our knowle...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2004.117 |
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| _version_ | 1832551887675588608 |
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| author | Evan Pisick Simha Jagadeesh Ravi Salgia |
| author_facet | Evan Pisick Simha Jagadeesh Ravi Salgia |
| author_sort | Evan Pisick |
| collection | DOAJ |
| description | Lung cancer is a deadly disease with high mortality and morbidity. Most cases of lung cancer are due to non-small cell carcinoma, with 16% of cases being small cell carcinoma. The biology at a cellular level is of interest at many levels. Knowing cellular pathways helps to further enhance our knowledge of how lung cancer cells survive, proliferate, and metastasize. The receptor tyrosine kinases (RTKs) located at the cellular membrane are becoming of great interest as sites for targeted therapies for lung cancers. This review will discuss the RTKs that are involved in lung cancers and the newer therapies that are being tested. We will specifically discuss receptors such as epidermal growth factor receptor, c-Kit receptor, VEGF receptor, c-Met receptor, insulin growth factor receptor, and Eph receptor. The inhibitors against the specific RTKs are in various preclinical and clinical trials, and this will be detailed. |
| format | Article |
| id | doaj-art-7e184039e6a747909c08f5d59c44731c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7e184039e6a747909c08f5d59c44731c2025-02-03T06:00:07ZengWileyThe Scientific World Journal1537-744X2004-01-01458960410.1100/tsw.2004.117Receptor Tyrosine Kinases and Inhibitors in Lung CancerEvan Pisick0Simha Jagadeesh1Ravi Salgia2Tufts-New England Medical Center, Tufts University School of Medicine, Boston MA, USAUniversity of Chicago, Section of Hematology and Oncology, Pritzker Medical School, Chicago, IL, USAUniversity of Chicago, Section of Hematology and Oncology, Pritzker Medical School, Chicago, IL, USALung cancer is a deadly disease with high mortality and morbidity. Most cases of lung cancer are due to non-small cell carcinoma, with 16% of cases being small cell carcinoma. The biology at a cellular level is of interest at many levels. Knowing cellular pathways helps to further enhance our knowledge of how lung cancer cells survive, proliferate, and metastasize. The receptor tyrosine kinases (RTKs) located at the cellular membrane are becoming of great interest as sites for targeted therapies for lung cancers. This review will discuss the RTKs that are involved in lung cancers and the newer therapies that are being tested. We will specifically discuss receptors such as epidermal growth factor receptor, c-Kit receptor, VEGF receptor, c-Met receptor, insulin growth factor receptor, and Eph receptor. The inhibitors against the specific RTKs are in various preclinical and clinical trials, and this will be detailed.http://dx.doi.org/10.1100/tsw.2004.117 |
| spellingShingle | Evan Pisick Simha Jagadeesh Ravi Salgia Receptor Tyrosine Kinases and Inhibitors in Lung Cancer The Scientific World Journal |
| title | Receptor Tyrosine Kinases and Inhibitors in Lung Cancer |
| title_full | Receptor Tyrosine Kinases and Inhibitors in Lung Cancer |
| title_fullStr | Receptor Tyrosine Kinases and Inhibitors in Lung Cancer |
| title_full_unstemmed | Receptor Tyrosine Kinases and Inhibitors in Lung Cancer |
| title_short | Receptor Tyrosine Kinases and Inhibitors in Lung Cancer |
| title_sort | receptor tyrosine kinases and inhibitors in lung cancer |
| url | http://dx.doi.org/10.1100/tsw.2004.117 |
| work_keys_str_mv | AT evanpisick receptortyrosinekinasesandinhibitorsinlungcancer AT simhajagadeesh receptortyrosinekinasesandinhibitorsinlungcancer AT ravisalgia receptortyrosinekinasesandinhibitorsinlungcancer |