Increased interferon I signaling, DNA damage response and evidence of T-cell exhaustion in a patient with combined interferonopathy (Aicardi-Goutières Syndrome, AGS) and cohesinopathy (Cornelia de Lange Syndrome, CdLS)

Abstract Background Type I interferonopathies including Aicardi-Goutiéres Syndrome (AGS) represent a heterogeneous group of clinical phenotypes. Herein, we present a Case with combined AGS and Cornelia de Lange Syndrome (CdLS)—a cohesinopathy—with comprehensive analysis of the immune and genomic abn...

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Bibliographic Details
Main Authors:	Sorina Boiu, Nikolaos Paschalidis, George Sentis, Theodora Manolakou, Andrianos Nezos, Manolis Gialitakis, Maria Grigoriou, Erato Atsali, Melpomeni Giorgi, Argirios Ntinopoulos, Clio Mavragani, Periklis Makrythanasis, Dimitrios T. Boumpas, Aggelos Banos
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	Pediatric Rheumatology Online Journal
Subjects:	Lupus Interferonopathy Cohesinopathy DNA damage response Aicardi-Goutiéres Syndrome Cornelia de Lange Syndrome
Online Access:	https://doi.org/10.1186/s12969-024-01050-7
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