Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism
Neuropathic pain (NP) is pain caused by somatosensory nervous system injury or disease. Its prominent symptoms are spontaneous pain, hyperalgesia, and allodynia, and the sense of pain is extremely strong. Owing to the complex mechanism, conventional painkillers lack effectiveness. Recently, research...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8861251 |
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| author | Meichen Liu Kai Li Yunyun Wang Guoqing Zhao Jinlan Jiang |
| author_facet | Meichen Liu Kai Li Yunyun Wang Guoqing Zhao Jinlan Jiang |
| author_sort | Meichen Liu |
| collection | DOAJ |
| description | Neuropathic pain (NP) is pain caused by somatosensory nervous system injury or disease. Its prominent symptoms are spontaneous pain, hyperalgesia, and allodynia, and the sense of pain is extremely strong. Owing to the complex mechanism, conventional painkillers lack effectiveness. Recently, research on the treatment of NP by stem cells is increasing and promising results have been achieved in preclinical research. In this review, we briefly introduce the neuropathic pain, the current treatment strategy, and the development of stem cell therapy, and we collected the experimental and clinical trial articles of many kinds of stem cells in the treatment of neuropathic pain from the past ten years. We analyzed and summarized the general efficacy and mechanism of stem cells in the treatment of neuropathic pain. We found that the multiple-mechanism approach was different from the single mechanism of routine clinical drugs; stem cells play a role in peripheral mechanism, central mechanism, and disinhibition of spinal cord level that lead to neuropathic pain, so they are more effective in analgesia and treatment of neuropathic pain. |
| format | Article |
| id | doaj-art-7dfc197a9ed0443db091823bd3cab40f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-7dfc197a9ed0443db091823bd3cab40f2025-02-03T01:20:50ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88612518861251Stem Cells in the Treatment of Neuropathic Pain: Research Progress of MechanismMeichen Liu0Kai Li1Yunyun Wang2Guoqing Zhao3Jinlan Jiang4Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, ChinaNeuropathic pain (NP) is pain caused by somatosensory nervous system injury or disease. Its prominent symptoms are spontaneous pain, hyperalgesia, and allodynia, and the sense of pain is extremely strong. Owing to the complex mechanism, conventional painkillers lack effectiveness. Recently, research on the treatment of NP by stem cells is increasing and promising results have been achieved in preclinical research. In this review, we briefly introduce the neuropathic pain, the current treatment strategy, and the development of stem cell therapy, and we collected the experimental and clinical trial articles of many kinds of stem cells in the treatment of neuropathic pain from the past ten years. We analyzed and summarized the general efficacy and mechanism of stem cells in the treatment of neuropathic pain. We found that the multiple-mechanism approach was different from the single mechanism of routine clinical drugs; stem cells play a role in peripheral mechanism, central mechanism, and disinhibition of spinal cord level that lead to neuropathic pain, so they are more effective in analgesia and treatment of neuropathic pain.http://dx.doi.org/10.1155/2020/8861251 |
| spellingShingle | Meichen Liu Kai Li Yunyun Wang Guoqing Zhao Jinlan Jiang Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism Stem Cells International |
| title | Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism |
| title_full | Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism |
| title_fullStr | Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism |
| title_full_unstemmed | Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism |
| title_short | Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism |
| title_sort | stem cells in the treatment of neuropathic pain research progress of mechanism |
| url | http://dx.doi.org/10.1155/2020/8861251 |
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