MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury
Traumatic brain injury (TBI) occurs when a blow to the head causes brain damage. Apart from physical trauma, it causes a wide range of cognitive, behavioral, and emotional deficits including impairments in learning and memory. On neuronal level, TBI may lead to circuitry remodeling and in effect imb...
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/3259295 |
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| author | Barbara Pijet Marzena Stefaniuk Leszek Kaczmarek |
| author_facet | Barbara Pijet Marzena Stefaniuk Leszek Kaczmarek |
| author_sort | Barbara Pijet |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) occurs when a blow to the head causes brain damage. Apart from physical trauma, it causes a wide range of cognitive, behavioral, and emotional deficits including impairments in learning and memory. On neuronal level, TBI may lead to circuitry remodeling and in effect imbalance between excitatory and inhibitory neurotransmissions. Such change in brain homeostasis may often lead to brain disorders. The basic units of neuronal connectivity are dendritic spines that are tiny protrusions forming synapses between two cells in a network. Spines are dynamic structures that undergo morphological transformation throughout life. Their shape is strictly related to an on/off state of synapse and the strength of synaptic transmission. Matrix metalloproteinase-9 (MMP-9) is an extrasynaptically operating enzyme that plays a role in spine remodeling and has been reported to be activated upon TBI. The aim of the present study was to evaluate the influence of MMP-9 on dendritic spine density and morphology following controlled cortical impact (CCI) as animal model of TBI. We examined spine density and dendritic spine shape in the cerebral cortex and the hippocampus. CCI caused a marked decrease in spine density as well as spine shrinkage in the cerebral cortex ipsilateral to the injury, when compared to sham animals and contralateral side both 1 day and 1 week after the insult. Decreased spine density was also observed in the dentate gyrus of the hippocampus; however, in contrast to the cerebral cortex, spines in the DG became more filopodia-like. In mice lacking MMP-9, no effects of TBI on spine density and morphology were observed. |
| format | Article |
| id | doaj-art-7dfb48e4f8a044e492723cedfb233389 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | Neural Plasticity |
| spelling | doaj-art-7dfb48e4f8a044e492723cedfb2333892025-02-03T06:14:10ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/32592953259295MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain InjuryBarbara Pijet0Marzena Stefaniuk1Leszek Kaczmarek2Laboratory of Neurobiology, BRAINCITY, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteura 3, 02-093 Warsaw, PolandLaboratory of Neurobiology, BRAINCITY, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteura 3, 02-093 Warsaw, PolandLaboratory of Neurobiology, BRAINCITY, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteura 3, 02-093 Warsaw, PolandTraumatic brain injury (TBI) occurs when a blow to the head causes brain damage. Apart from physical trauma, it causes a wide range of cognitive, behavioral, and emotional deficits including impairments in learning and memory. On neuronal level, TBI may lead to circuitry remodeling and in effect imbalance between excitatory and inhibitory neurotransmissions. Such change in brain homeostasis may often lead to brain disorders. The basic units of neuronal connectivity are dendritic spines that are tiny protrusions forming synapses between two cells in a network. Spines are dynamic structures that undergo morphological transformation throughout life. Their shape is strictly related to an on/off state of synapse and the strength of synaptic transmission. Matrix metalloproteinase-9 (MMP-9) is an extrasynaptically operating enzyme that plays a role in spine remodeling and has been reported to be activated upon TBI. The aim of the present study was to evaluate the influence of MMP-9 on dendritic spine density and morphology following controlled cortical impact (CCI) as animal model of TBI. We examined spine density and dendritic spine shape in the cerebral cortex and the hippocampus. CCI caused a marked decrease in spine density as well as spine shrinkage in the cerebral cortex ipsilateral to the injury, when compared to sham animals and contralateral side both 1 day and 1 week after the insult. Decreased spine density was also observed in the dentate gyrus of the hippocampus; however, in contrast to the cerebral cortex, spines in the DG became more filopodia-like. In mice lacking MMP-9, no effects of TBI on spine density and morphology were observed.http://dx.doi.org/10.1155/2019/3259295 |
| spellingShingle | Barbara Pijet Marzena Stefaniuk Leszek Kaczmarek MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury Neural Plasticity |
| title | MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury |
| title_full | MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury |
| title_fullStr | MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury |
| title_full_unstemmed | MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury |
| title_short | MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury |
| title_sort | mmp 9 contributes to dendritic spine remodeling following traumatic brain injury |
| url | http://dx.doi.org/10.1155/2019/3259295 |
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