Bidirectional role of neutrophils in tumor development
Abstract Neutrophils, traditionally considered as non-specific components of the innate immune system, have garnered considerable research interest due to their dual roles in both promoting and inhibiting tumor progression. This paper seeks to clarify the specific mechanisms by which neutrophils pla...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-025-02228-7 |
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| author | Haoxin Luyang Feng Zeng Yan Lei Qian He Yanhong Zhou Juan Xu |
| author_facet | Haoxin Luyang Feng Zeng Yan Lei Qian He Yanhong Zhou Juan Xu |
| author_sort | Haoxin Luyang |
| collection | DOAJ |
| description | Abstract Neutrophils, traditionally considered as non-specific components of the innate immune system, have garnered considerable research interest due to their dual roles in both promoting and inhibiting tumor progression. This paper seeks to clarify the specific mechanisms by which neutrophils play a bidirectional role in tumor immunity and the factors that influence these roles. By conducting a comprehensive analysis and synthesis of a vast array of relevant literature, it has become evident that neutrophils can influence tumor development and invasive migration through various mechanisms, thereby exerting their anti-tumor effects. Conversely, they can also facilitate tumorigenesis and proliferation, as well as affect the normal physiological functions of other immune cells, thus exerting pro-tumor effects. Moreover, neutrophils are influenced by tumor cells and their unique microenvironment, which in turn affects their heterogeneity and plasticity. Neutrophils interact with tumor cells to regulate various aspects of their life activities precisely. This paper also identifies unresolved issues in the research concerning the bidirectional role of neutrophils in tumorigenesis and tumor development, offering new opportunities and challenges for advancing our understanding. This, in turn, can aid in the proper application of these insights to clinical treatment strategies. |
| format | Article |
| id | doaj-art-7df5bf44681c4587bbda6459c44d3feb |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-7df5bf44681c4587bbda6459c44d3feb2025-01-19T12:12:41ZengBMCMolecular Cancer1476-45982025-01-0124111610.1186/s12943-025-02228-7Bidirectional role of neutrophils in tumor developmentHaoxin Luyang0Feng Zeng1Yan Lei2Qian He3Yanhong Zhou4Juan Xu5Department of critical care medicine, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer HospitalCancer Research Institute, Basic School of Medicine, Central South UniversityDepartment of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer HospitalDepartment of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer HospitalCancer Research Institute, Basic School of Medicine, Central South UniversityDepartment of critical care medicine, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer HospitalAbstract Neutrophils, traditionally considered as non-specific components of the innate immune system, have garnered considerable research interest due to their dual roles in both promoting and inhibiting tumor progression. This paper seeks to clarify the specific mechanisms by which neutrophils play a bidirectional role in tumor immunity and the factors that influence these roles. By conducting a comprehensive analysis and synthesis of a vast array of relevant literature, it has become evident that neutrophils can influence tumor development and invasive migration through various mechanisms, thereby exerting their anti-tumor effects. Conversely, they can also facilitate tumorigenesis and proliferation, as well as affect the normal physiological functions of other immune cells, thus exerting pro-tumor effects. Moreover, neutrophils are influenced by tumor cells and their unique microenvironment, which in turn affects their heterogeneity and plasticity. Neutrophils interact with tumor cells to regulate various aspects of their life activities precisely. This paper also identifies unresolved issues in the research concerning the bidirectional role of neutrophils in tumorigenesis and tumor development, offering new opportunities and challenges for advancing our understanding. This, in turn, can aid in the proper application of these insights to clinical treatment strategies.https://doi.org/10.1186/s12943-025-02228-7NeutrophilsTumor immunityAnti-tumor effectsTumor-promoting effectsBidirectional role |
| spellingShingle | Haoxin Luyang Feng Zeng Yan Lei Qian He Yanhong Zhou Juan Xu Bidirectional role of neutrophils in tumor development Molecular Cancer Neutrophils Tumor immunity Anti-tumor effects Tumor-promoting effects Bidirectional role |
| title | Bidirectional role of neutrophils in tumor development |
| title_full | Bidirectional role of neutrophils in tumor development |
| title_fullStr | Bidirectional role of neutrophils in tumor development |
| title_full_unstemmed | Bidirectional role of neutrophils in tumor development |
| title_short | Bidirectional role of neutrophils in tumor development |
| title_sort | bidirectional role of neutrophils in tumor development |
| topic | Neutrophils Tumor immunity Anti-tumor effects Tumor-promoting effects Bidirectional role |
| url | https://doi.org/10.1186/s12943-025-02228-7 |
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