Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis
Herpes virus type 2 DNA was detected by PCR in the cerebrospinal fluid in a young woman presenting with headache, stiff neck and pleocytosis, and serological findings consistent with reactivation. Since she was exposed to ticks, Lyme disease and tick-borne encephalitis were excluded. Further investi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2011/469194 |
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| _version_ | 1832558109687545856 |
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| author | Kenneth Nilsson Katarina Wallménius Carl Påhlson |
| author_facet | Kenneth Nilsson Katarina Wallménius Carl Påhlson |
| author_sort | Kenneth Nilsson |
| collection | DOAJ |
| description | Herpes virus type 2 DNA was detected by PCR in the cerebrospinal fluid in a young woman presenting with headache, stiff neck and pleocytosis, and serological findings consistent with reactivation. Since she was exposed to ticks, Lyme disease and tick-borne encephalitis were excluded. Further investigation in an ongoing project, using PCR and sequencing of the amplified products, showed the presence of Rickettsia helvetica in the cerebrospinal fluid. The bacteria were also isolated in Vero cell culture, and microimmunofluorescence confirmed the development of antibodies against Rickettsia spp. with predominance of IgM reactivity consistent with recent infection. She was treated with antibiotics and improved rapidly. The patient could easily have been judged to have isolated herpes meningitis. Because Sweden and other European countries are endemic areas for rickettsioses, the paper reaffirms the importance of investigating for the presence of rickettsial infections in endemic areas in cases of meningitis of uncertain aetiology. |
| format | Article |
| id | doaj-art-7df2034d647e43569aa2d52f8d23d7c6 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-7df2034d647e43569aa2d52f8d23d7c62025-02-03T01:33:10ZengWileyCase Reports in Infectious Diseases2090-66252090-66332011-01-01201110.1155/2011/469194469194Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with MeningoencephalitisKenneth Nilsson0Katarina Wallménius1Carl Påhlson2Section of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 85 Uppsala, SwedenSection of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 85 Uppsala, SwedenSection of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 85 Uppsala, SwedenHerpes virus type 2 DNA was detected by PCR in the cerebrospinal fluid in a young woman presenting with headache, stiff neck and pleocytosis, and serological findings consistent with reactivation. Since she was exposed to ticks, Lyme disease and tick-borne encephalitis were excluded. Further investigation in an ongoing project, using PCR and sequencing of the amplified products, showed the presence of Rickettsia helvetica in the cerebrospinal fluid. The bacteria were also isolated in Vero cell culture, and microimmunofluorescence confirmed the development of antibodies against Rickettsia spp. with predominance of IgM reactivity consistent with recent infection. She was treated with antibiotics and improved rapidly. The patient could easily have been judged to have isolated herpes meningitis. Because Sweden and other European countries are endemic areas for rickettsioses, the paper reaffirms the importance of investigating for the presence of rickettsial infections in endemic areas in cases of meningitis of uncertain aetiology.http://dx.doi.org/10.1155/2011/469194 |
| spellingShingle | Kenneth Nilsson Katarina Wallménius Carl Påhlson Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis Case Reports in Infectious Diseases |
| title | Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis |
| title_full | Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis |
| title_fullStr | Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis |
| title_full_unstemmed | Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis |
| title_short | Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis |
| title_sort | coinfection with rickettsia helvetica and herpes simplex virus 2 in a young woman with meningoencephalitis |
| url | http://dx.doi.org/10.1155/2011/469194 |
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