(3a,8b)-5-Acetyl-3a-fluoro-6,8-dihydroxy-7,8b-dimethyl-3,3a-dihydrofuro[3,2-b]benzofuran-2(8bH)-one
Usnetic acid is a dibenzofuran-2-ylacetic acid that can be obtained by alkaline degradation of a secondary lichen metabolite—usnic acid. In the present paper, the product of the reaction of usnetic acid with a mild fluorinating agent, Selectfluor<sup>®</sup>, was obtained. The structure...
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2025-04-01
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| author | Aleksandr S. Filimonov Stepan P. Zernov Olga A. Luzina Nariman F. Salakhutdinov |
| author_facet | Aleksandr S. Filimonov Stepan P. Zernov Olga A. Luzina Nariman F. Salakhutdinov |
| author_sort | Aleksandr S. Filimonov |
| collection | DOAJ |
| description | Usnetic acid is a dibenzofuran-2-ylacetic acid that can be obtained by alkaline degradation of a secondary lichen metabolite—usnic acid. In the present paper, the product of the reaction of usnetic acid with a mild fluorinating agent, Selectfluor<sup>®</sup>, was obtained. The structure of the product was proved by a set of physical methods, including <sup>1</sup>H, <sup>13</sup>C, <sup>19</sup>F NMR, HMBC, HSQC, HRMS and IR spectroscopy. |
| format | Article |
| id | doaj-art-7def724bdfd64310a30ba97cb02e1d4a |
| institution | Kabale University |
| issn | 1422-8599 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj-art-7def724bdfd64310a30ba97cb02e1d4a2025-08-20T03:27:32ZengMDPI AGMolbank1422-85992025-04-0120252M199510.3390/M1995(3a,8b)-5-Acetyl-3a-fluoro-6,8-dihydroxy-7,8b-dimethyl-3,3a-dihydrofuro[3,2-b]benzofuran-2(8bH)-oneAleksandr S. Filimonov0Stepan P. Zernov1Olga A. Luzina2Nariman F. Salakhutdinov3Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentieva Ave., 630090 Novosibirsk, RussiaDepartment of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentieva Ave., 630090 Novosibirsk, RussiaDepartment of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentieva Ave., 630090 Novosibirsk, RussiaDepartment of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentieva Ave., 630090 Novosibirsk, RussiaUsnetic acid is a dibenzofuran-2-ylacetic acid that can be obtained by alkaline degradation of a secondary lichen metabolite—usnic acid. In the present paper, the product of the reaction of usnetic acid with a mild fluorinating agent, Selectfluor<sup>®</sup>, was obtained. The structure of the product was proved by a set of physical methods, including <sup>1</sup>H, <sup>13</sup>C, <sup>19</sup>F NMR, HMBC, HSQC, HRMS and IR spectroscopy.https://www.mdpi.com/1422-8599/2025/2/M1995usnetic acidfluorinationSelectfluor<sup>®</sup> |
| spellingShingle | Aleksandr S. Filimonov Stepan P. Zernov Olga A. Luzina Nariman F. Salakhutdinov (3a,8b)-5-Acetyl-3a-fluoro-6,8-dihydroxy-7,8b-dimethyl-3,3a-dihydrofuro[3,2-b]benzofuran-2(8bH)-one Molbank usnetic acid fluorination Selectfluor<sup>®</sup> |
| title | (3a,8b)-5-Acetyl-3a-fluoro-6,8-dihydroxy-7,8b-dimethyl-3,3a-dihydrofuro[3,2-b]benzofuran-2(8bH)-one |
| title_full | (3a,8b)-5-Acetyl-3a-fluoro-6,8-dihydroxy-7,8b-dimethyl-3,3a-dihydrofuro[3,2-b]benzofuran-2(8bH)-one |
| title_fullStr | (3a,8b)-5-Acetyl-3a-fluoro-6,8-dihydroxy-7,8b-dimethyl-3,3a-dihydrofuro[3,2-b]benzofuran-2(8bH)-one |
| title_full_unstemmed | (3a,8b)-5-Acetyl-3a-fluoro-6,8-dihydroxy-7,8b-dimethyl-3,3a-dihydrofuro[3,2-b]benzofuran-2(8bH)-one |
| title_short | (3a,8b)-5-Acetyl-3a-fluoro-6,8-dihydroxy-7,8b-dimethyl-3,3a-dihydrofuro[3,2-b]benzofuran-2(8bH)-one |
| title_sort | 3a 8b 5 acetyl 3a fluoro 6 8 dihydroxy 7 8b dimethyl 3 3a dihydrofuro 3 2 b benzofuran 2 8bh one |
| topic | usnetic acid fluorination Selectfluor<sup>®</sup> |
| url | https://www.mdpi.com/1422-8599/2025/2/M1995 |
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