The pancreatic tumor microenvironment of treatment-naïve patients causes a functional shift in γδ T cells, impairing their anti-tumoral defense

The pancreatic tumor microenvironment of treatment-naïve patients causes a functional shift in γδ T cells, impairing their anti-tumoral defense

Pancreatic ductal adenocarcinoma (PDAC) presents a unique challenge for researchers due to its late diagnosis caused by vague symptoms and lack of early detection markers. Additionally, PDAC is characterized by an immunosuppressive microenvironment (TME), making it a difficult tumor to treat. While...

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Bibliographic Details
Main Authors: Elena Lo Presti, Francesca Cupaioli, Daniela Scimeca, Elettra Unti, Vincenzo Di Martino, Rossella Daidone, Michele Amata, Nunzia Scibetta, Erinn Soucie, Serena Meraviglia, Juan Iovanna, Nelson Dusetti, Andrea De Gaetano, Ivan Merelli, Roberto Di Mitri
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Fine-needle biopsies
gamma delta T cells
immune checkpoints
immunotherapy
patient derived organoids
PDAC
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2466301
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