Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking

Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking

<b>Background/Objectives</b>: Although donepezil, a reversible acetylcholinesterase inhibitor, has been in use since 1996, its metabolic characteristics remain poorly characterized. Therefore, this study aims to investigate the in vivo metabolism of donepezil using liquid chromatography–...

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Bibliographic Details
Main Authors: Eun-Ji Park, Eui-Hyeon Kim, Ki-Young Kim, Ji-Hyeon Jeon, Im-Sook Song, So-Young Park, Kwang-Hyeon Liu
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceutics
Subjects:
donepezil
mass spectrometry
metabolism
molecular networking
nontargeted metabolomics
Online Access:https://www.mdpi.com/1999-4923/17/1/115
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