Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue.
<h4>Objectives</h4>To evaluate sources of error in the Magnetic Resonance Imaging (MRI) measurement of percent fibroglandular tissue (%FGT) using two-point Dixon sequences for fat-water separation.<h4>Methods</h4>Ten female volunteers (median age: 31 yrs, range: 23-50 yrs) ga...
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152152&type=printable |
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| author | Araminta E W Ledger Erica D Scurr Julie Hughes Alison Macdonald Toni Wallace Karen Thomas Robin Wilson Martin O Leach Maria A Schmidt |
| author_facet | Araminta E W Ledger Erica D Scurr Julie Hughes Alison Macdonald Toni Wallace Karen Thomas Robin Wilson Martin O Leach Maria A Schmidt |
| author_sort | Araminta E W Ledger |
| collection | DOAJ |
| description | <h4>Objectives</h4>To evaluate sources of error in the Magnetic Resonance Imaging (MRI) measurement of percent fibroglandular tissue (%FGT) using two-point Dixon sequences for fat-water separation.<h4>Methods</h4>Ten female volunteers (median age: 31 yrs, range: 23-50 yrs) gave informed consent following Research Ethics Committee approval. Each volunteer was scanned twice following repositioning to enable an estimation of measurement repeatability from high-resolution gradient-echo (GRE) proton-density (PD)-weighted Dixon sequences. Differences in measures of %FGT attributable to resolution, T1 weighting and sequence type were assessed by comparison of this Dixon sequence with low-resolution GRE PD-weighted Dixon data, and against gradient-echo (GRE) or spin-echo (SE) based T1-weighted Dixon datasets, respectively.<h4>Results</h4>%FGT measurement from high-resolution PD-weighted Dixon sequences had a coefficient of repeatability of ±4.3%. There was no significant difference in %FGT between high-resolution and low-resolution PD-weighted data. Values of %FGT from GRE and SE T1-weighted data were strongly correlated with that derived from PD-weighted data (r = 0.995 and 0.96, respectively). However, both sequences exhibited higher mean %FGT by 2.9% (p < 0.0001) and 12.6% (p < 0.0001), respectively, in comparison with PD-weighted data; the increase in %FGT from the SE T1-weighted sequence was significantly larger at lower breast densities.<h4>Conclusion</h4>Although measurement of %FGT at low resolution is feasible, T1 weighting and sequence type impact on the accuracy of Dixon-based %FGT measurements; Dixon MRI protocols for %FGT measurement should be carefully considered, particularly for longitudinal or multi-centre studies. |
| format | Article |
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| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7de2f0ef76cb4fc7bd80ff55e72bc8492025-08-20T02:31:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015215210.1371/journal.pone.0152152Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue.Araminta E W LedgerErica D ScurrJulie HughesAlison MacdonaldToni WallaceKaren ThomasRobin WilsonMartin O LeachMaria A Schmidt<h4>Objectives</h4>To evaluate sources of error in the Magnetic Resonance Imaging (MRI) measurement of percent fibroglandular tissue (%FGT) using two-point Dixon sequences for fat-water separation.<h4>Methods</h4>Ten female volunteers (median age: 31 yrs, range: 23-50 yrs) gave informed consent following Research Ethics Committee approval. Each volunteer was scanned twice following repositioning to enable an estimation of measurement repeatability from high-resolution gradient-echo (GRE) proton-density (PD)-weighted Dixon sequences. Differences in measures of %FGT attributable to resolution, T1 weighting and sequence type were assessed by comparison of this Dixon sequence with low-resolution GRE PD-weighted Dixon data, and against gradient-echo (GRE) or spin-echo (SE) based T1-weighted Dixon datasets, respectively.<h4>Results</h4>%FGT measurement from high-resolution PD-weighted Dixon sequences had a coefficient of repeatability of ±4.3%. There was no significant difference in %FGT between high-resolution and low-resolution PD-weighted data. Values of %FGT from GRE and SE T1-weighted data were strongly correlated with that derived from PD-weighted data (r = 0.995 and 0.96, respectively). However, both sequences exhibited higher mean %FGT by 2.9% (p < 0.0001) and 12.6% (p < 0.0001), respectively, in comparison with PD-weighted data; the increase in %FGT from the SE T1-weighted sequence was significantly larger at lower breast densities.<h4>Conclusion</h4>Although measurement of %FGT at low resolution is feasible, T1 weighting and sequence type impact on the accuracy of Dixon-based %FGT measurements; Dixon MRI protocols for %FGT measurement should be carefully considered, particularly for longitudinal or multi-centre studies.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152152&type=printable |
| spellingShingle | Araminta E W Ledger Erica D Scurr Julie Hughes Alison Macdonald Toni Wallace Karen Thomas Robin Wilson Martin O Leach Maria A Schmidt Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue. PLoS ONE |
| title | Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue. |
| title_full | Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue. |
| title_fullStr | Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue. |
| title_full_unstemmed | Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue. |
| title_short | Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue. |
| title_sort | comparison of dixon sequences for estimation of percent breast fibroglandular tissue |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152152&type=printable |
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