Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer

Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer

Abstract Epithelial-mesenchymal transition (EMT) is designated as one of the prime causes of chemoresistance in many cancers. In our previous study we established that cisplatin resistance in ovarian cancer (OC) is associated with EMT using sensitive OV90 cells and its resistant counterparts OV90Cis...

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Bibliographic Details
Main Authors: Taha Umair Wani, Hyun-Yi Kim, Geum-Hwa Lee, Young Je Lim, Han-Jung Chae, Ji-Ye Kim, Hyonok Yoon
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Ovarian cancer
Cisplatin resistance
RNA sequencing
EMT
Integrins
Online Access:https://doi.org/10.1038/s41598-025-87388-8
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