Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular Function
Background. Obesity and low cardiorespiratory fitness (CRF) have been shown to independently increase the risk of CVD mortality. The aim of this study was to investigate the relationship between CRF, body fatness and markers of arterial function. Method and Results. Obese (9 male, 18 female; BMI 35...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2010/191253 |
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| author | Kade Davison Stefan Bircher Alison Hill Alison M. Coates Peter R. C. Howe Jonathan D. Buckley |
| author_facet | Kade Davison Stefan Bircher Alison Hill Alison M. Coates Peter R. C. Howe Jonathan D. Buckley |
| author_sort | Kade Davison |
| collection | DOAJ |
| description | Background. Obesity and low cardiorespiratory fitness (CRF) have been shown to independently increase the risk of CVD mortality. The aim of this study was to investigate the relationship between CRF, body fatness and markers of arterial function. Method and Results. Obese (9 male, 18 female; BMI 35.3 ± 0.9 kg·m-2) and lean (8 male, 18 female; BMI 22.5 ± 0.3 kg·m-2) volunteers were assessed for body composition (DXA), cardiorespiratory fitness (predicted ̇VO2max), blood pressure (BP), endothelial vasodilatator function (FMD), and arterial compliance (AC) (via radial artery tonometry). The obese group had more whole body fat and abdominal fat (43.5 ± 1.2% versus 27.2 ± 1.6%; 𝑃<.001 and 48.6 ± 0.9% versus 28.9 ± 1.8%; 𝑃<.001, resp.), and lower FMD (3.2 ± 0.4% versus 5.7 ± 0.7%; 𝑃<.01) than the lean subjects, but there was no difference in AC. AC in large arteries was positively associated with CRF (R=0.5; 𝑃<.01) but not with fatness. Conclusion. These results indicate distinct influences of obesity and CRF on blood vessel health. FMD was impaired with obesity, which may contribute to arterial and metabolic dysfunction. Low CRF was associated with reduced elasticity in large arteries, which could result in augmentation of aortic afterload. |
| format | Article |
| id | doaj-art-7dd27cb4204943cb9894992356f95bf9 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-7dd27cb4204943cb9894992356f95bf92025-02-03T05:43:42ZengWileyJournal of Obesity2090-07082090-07162010-01-01201010.1155/2010/191253191253Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular FunctionKade Davison0Stefan Bircher1Alison Hill2Alison M. Coates3Peter R. C. Howe4Jonathan D. Buckley5Nutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, School of Health Sciences, University of South Australia, SA 5001, AustraliaNutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, School of Health Sciences, University of South Australia, SA 5001, AustraliaNutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, School of Health Sciences, University of South Australia, SA 5001, AustraliaNutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, School of Health Sciences, University of South Australia, SA 5001, AustraliaNutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, School of Health Sciences, University of South Australia, SA 5001, AustraliaNutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, School of Health Sciences, University of South Australia, SA 5001, AustraliaBackground. Obesity and low cardiorespiratory fitness (CRF) have been shown to independently increase the risk of CVD mortality. The aim of this study was to investigate the relationship between CRF, body fatness and markers of arterial function. Method and Results. Obese (9 male, 18 female; BMI 35.3 ± 0.9 kg·m-2) and lean (8 male, 18 female; BMI 22.5 ± 0.3 kg·m-2) volunteers were assessed for body composition (DXA), cardiorespiratory fitness (predicted ̇VO2max), blood pressure (BP), endothelial vasodilatator function (FMD), and arterial compliance (AC) (via radial artery tonometry). The obese group had more whole body fat and abdominal fat (43.5 ± 1.2% versus 27.2 ± 1.6%; 𝑃<.001 and 48.6 ± 0.9% versus 28.9 ± 1.8%; 𝑃<.001, resp.), and lower FMD (3.2 ± 0.4% versus 5.7 ± 0.7%; 𝑃<.01) than the lean subjects, but there was no difference in AC. AC in large arteries was positively associated with CRF (R=0.5; 𝑃<.01) but not with fatness. Conclusion. These results indicate distinct influences of obesity and CRF on blood vessel health. FMD was impaired with obesity, which may contribute to arterial and metabolic dysfunction. Low CRF was associated with reduced elasticity in large arteries, which could result in augmentation of aortic afterload.http://dx.doi.org/10.1155/2010/191253 |
| spellingShingle | Kade Davison Stefan Bircher Alison Hill Alison M. Coates Peter R. C. Howe Jonathan D. Buckley Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular Function Journal of Obesity |
| title | Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular Function |
| title_full | Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular Function |
| title_fullStr | Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular Function |
| title_full_unstemmed | Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular Function |
| title_short | Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular Function |
| title_sort | relationships between obesity cardiorespiratory fitness and cardiovascular function |
| url | http://dx.doi.org/10.1155/2010/191253 |
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