The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions
A study of the effect of high altitude (Tuya-Ashu Pass, 3200 m above sea level and Bishkek, 720 m above sea level) on rat metabolism demonstrated significant changes in the lipid profile and oxidative stress levels after three days of exposure to low oxygen availability. There was a significant incr...
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EDP Sciences
2025-01-01
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| Series: | E3S Web of Conferences |
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| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/08/e3sconf_eenviro2024_03004.pdf |
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| author | Gulbarchyn Alisherovna Asrankulova Zhyldyz Akmatovna Makhmudova Zyinat Samidinovna Boronova Meerim Taalaibekovna Taalaibekova Zhyldyz Turusbekovna Ayipova Unsun Satarkulovna Torobaeva |
| author_facet | Gulbarchyn Alisherovna Asrankulova Zhyldyz Akmatovna Makhmudova Zyinat Samidinovna Boronova Meerim Taalaibekovna Taalaibekova Zhyldyz Turusbekovna Ayipova Unsun Satarkulovna Torobaeva |
| author_sort | Gulbarchyn Alisherovna Asrankulova |
| collection | DOAJ |
| description | A study of the effect of high altitude (Tuya-Ashu Pass, 3200 m above sea level and Bishkek, 720 m above sea level) on rat metabolism demonstrated significant changes in the lipid profile and oxidative stress levels after three days of exposure to low oxygen availability. There was a significant increase in total cholesterol and triglyceride levels, indicating disturbances in lipid metabolism and may be indicative of hyperlipidemia. Low density lipoproteins (LDL) levels increased significantly, while high density lipoproteins (HDL) levels decreased significantly, which is likely associated with worsening cardiovascular health and an increased risk of atherosclerosis. Malondialdehyde (MDA) levels increased, indicating increased oxidative stress as a result of adaptation to high altitude conditions. Increased activity of superoxide dismutase (SOD) and catalase enzymes confirms that the rats’ bodies are trying to adapt to increased oxidative stress by activating free radical defense mechanisms. Oral administration of ω-3 fatty acids at a dose of 300 mg/kg of animal body weight once a day for 30 days leads to a decrease in the levels of atherogenic low-density lipoproteins, malondialdehyde, increase the level of anti-atherogenic high-density lipoproteins and activity of superoxide dismutase and catalase. |
| format | Article |
| id | doaj-art-7dd02b9513a749eeaac1884908a34119 |
| institution | Kabale University |
| issn | 2267-1242 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj-art-7dd02b9513a749eeaac1884908a341192025-02-05T10:49:33ZengEDP SciencesE3S Web of Conferences2267-12422025-01-016080300410.1051/e3sconf/202560803004e3sconf_eenviro2024_03004The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditionsGulbarchyn Alisherovna Asrankulova0Zhyldyz Akmatovna Makhmudova1Zyinat Samidinovna Boronova2Meerim Taalaibekovna Taalaibekova3Zhyldyz Turusbekovna Ayipova4Unsun Satarkulovna Torobaeva5Department of Biochemistry with a course of general and bioorganic chemistry named after A.Dzh. Dzhumaliev, I.K. Akhunbaev Kyrgyz State Medical AcademyDepartment of Biochemistry with a course of general and bioorganic chemistry named after A.Dzh. Dzhumaliev, I.K. Akhunbaev Kyrgyz State Medical AcademyDepartment of Pharmaceutical Chemistry and Drug Technology, Osh State UniversityDepartment of Biochemistry with a course of general and bioorganic chemistry named after A.Dzh. Dzhumaliev, I.K. Akhunbaev Kyrgyz State Medical AcademyDepartment of Biochemistry with a course of general and bioorganic chemistry named after A.Dzh. Dzhumaliev, I.K. Akhunbaev Kyrgyz State Medical AcademyDepartment of Pharmaceutical Chemistry and Drug Technology, Osh State UniversityA study of the effect of high altitude (Tuya-Ashu Pass, 3200 m above sea level and Bishkek, 720 m above sea level) on rat metabolism demonstrated significant changes in the lipid profile and oxidative stress levels after three days of exposure to low oxygen availability. There was a significant increase in total cholesterol and triglyceride levels, indicating disturbances in lipid metabolism and may be indicative of hyperlipidemia. Low density lipoproteins (LDL) levels increased significantly, while high density lipoproteins (HDL) levels decreased significantly, which is likely associated with worsening cardiovascular health and an increased risk of atherosclerosis. Malondialdehyde (MDA) levels increased, indicating increased oxidative stress as a result of adaptation to high altitude conditions. Increased activity of superoxide dismutase (SOD) and catalase enzymes confirms that the rats’ bodies are trying to adapt to increased oxidative stress by activating free radical defense mechanisms. Oral administration of ω-3 fatty acids at a dose of 300 mg/kg of animal body weight once a day for 30 days leads to a decrease in the levels of atherogenic low-density lipoproteins, malondialdehyde, increase the level of anti-atherogenic high-density lipoproteins and activity of superoxide dismutase and catalase.https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/08/e3sconf_eenviro2024_03004.pdfhighlandsaginglipid profileantioxidant systemω-3 fatty acids |
| spellingShingle | Gulbarchyn Alisherovna Asrankulova Zhyldyz Akmatovna Makhmudova Zyinat Samidinovna Boronova Meerim Taalaibekovna Taalaibekova Zhyldyz Turusbekovna Ayipova Unsun Satarkulovna Torobaeva The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions E3S Web of Conferences highlands aging lipid profile antioxidant system ω-3 fatty acids |
| title | The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions |
| title_full | The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions |
| title_fullStr | The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions |
| title_full_unstemmed | The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions |
| title_short | The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions |
| title_sort | state of lipid metabolism on the background of the use of ω 3 fatty acids in high altitude conditions |
| topic | highlands aging lipid profile antioxidant system ω-3 fatty acids |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/08/e3sconf_eenviro2024_03004.pdf |
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