The correlation between coagulation biomarkers, bone turnover markers, and bone mineral density in Chinese adults aged ≥ 50 years
Introduction Osteoporosis patients undergoing surgery often have significant bleeding, which is closely related to coagulation function. This study aimed to assess the correlation between bone turnover markers (BTMs), bone mineral density (BMD), and coagulation biomarkers. Material and methods Case...
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| Language: | English |
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Termedia Publishing House
2024-03-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/The-correlation-between-coagulation-biomarkers-bone-nturnover-markers-and-bone-mineral,184346,0,2.html |
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| author | Zhengming Wang Rui Wang Haiya Ge Yong Gu Sicheng Xian Laijun Yan Guoqing Du Zhibi Shen Shuaijie Lv Hongsheng Zhan Zhengyan Li |
| author_facet | Zhengming Wang Rui Wang Haiya Ge Yong Gu Sicheng Xian Laijun Yan Guoqing Du Zhibi Shen Shuaijie Lv Hongsheng Zhan Zhengyan Li |
| author_sort | Zhengming Wang |
| collection | DOAJ |
| description | Introduction
Osteoporosis patients undergoing surgery often have significant bleeding, which is closely related to coagulation function. This study aimed to assess the correlation between bone turnover markers (BTMs), bone mineral density (BMD), and coagulation biomarkers.
Material and methods
Cases meeting the inclusion criteria were included from our center from January 2020 to December 2021. The relationships between coagulation biomarkers, BTMs, and BMD were investigated by Spearman correlation analysis and canonical correlation analysis (CCA). Consequently, age, bone mass stage, 25-hydroxyvitamin D (25-(OH)D), and BMD were included as independent variables in the logistic regression model. Furthermore, the international normalized ratio (INR), fibrinogen, platelets, and D-dimer levels were set as dependent variables in the regression analysis. Finally, multivariable regressions were conducted to adjust for differences in demographics and comorbidities among groups.
Results
A total of 306 patients were included in the study. Significant differences were observed in prothrombin time, fibrinogen, INR, D-dimer, and platelets (p < 0.05). D-dimer exhibited the most significant positive association with age and the most pronounced negative correlation with the BMD of Ward’s triangle (r = 0.322, p < 0.001; r = –0.298, p < 0.001; respectively). 25-(OH)D and calcium were related to coagulation biomarkers. Multivariate analysis demonstrated that age was positively associated with D-dimer levels (odd ratio [OR] = 1.046, p = 0.007), while the BMD of Ward’s triangle was negatively related to D-dimer levels (OR = 0.004, p = 0.0017).
Conclusions
For the Chinese population aged 50 and above, attention should be paid to alterations in coagulation biomarkers. |
| format | Article |
| id | doaj-art-7db13ae43917435b9c86ff3c3818fb3d |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-7db13ae43917435b9c86ff3c3818fb3d2025-01-27T10:45:12ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-03-012061854186310.5114/aoms/184346184346The correlation between coagulation biomarkers, bone turnover markers, and bone mineral density in Chinese adults aged ≥ 50 yearsZhengming Wang0Rui Wang1Haiya Ge2Yong Gu3Sicheng Xian4Laijun Yan5Guoqing Du6Zhibi Shen7Shuaijie Lv8Hongsheng Zhan9Zhengyan Li10Shi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, ChinaCenter of Orthopedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), ChinaShi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, ChinaCenter of Orthopedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), ChinaDepartment of Orthopedics, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangsu, ChinaShi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, ChinaShi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, ChinaShi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, ChinaCenter of Orthopedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), ChinaShi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, ChinaShi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, ChinaIntroduction Osteoporosis patients undergoing surgery often have significant bleeding, which is closely related to coagulation function. This study aimed to assess the correlation between bone turnover markers (BTMs), bone mineral density (BMD), and coagulation biomarkers. Material and methods Cases meeting the inclusion criteria were included from our center from January 2020 to December 2021. The relationships between coagulation biomarkers, BTMs, and BMD were investigated by Spearman correlation analysis and canonical correlation analysis (CCA). Consequently, age, bone mass stage, 25-hydroxyvitamin D (25-(OH)D), and BMD were included as independent variables in the logistic regression model. Furthermore, the international normalized ratio (INR), fibrinogen, platelets, and D-dimer levels were set as dependent variables in the regression analysis. Finally, multivariable regressions were conducted to adjust for differences in demographics and comorbidities among groups. Results A total of 306 patients were included in the study. Significant differences were observed in prothrombin time, fibrinogen, INR, D-dimer, and platelets (p < 0.05). D-dimer exhibited the most significant positive association with age and the most pronounced negative correlation with the BMD of Ward’s triangle (r = 0.322, p < 0.001; r = –0.298, p < 0.001; respectively). 25-(OH)D and calcium were related to coagulation biomarkers. Multivariate analysis demonstrated that age was positively associated with D-dimer levels (odd ratio [OR] = 1.046, p = 0.007), while the BMD of Ward’s triangle was negatively related to D-dimer levels (OR = 0.004, p = 0.0017). Conclusions For the Chinese population aged 50 and above, attention should be paid to alterations in coagulation biomarkers.https://www.archivesofmedicalscience.com/The-correlation-between-coagulation-biomarkers-bone-nturnover-markers-and-bone-mineral,184346,0,2.htmlcoagulationbone mineral densitybone turnover markercorrelation |
| spellingShingle | Zhengming Wang Rui Wang Haiya Ge Yong Gu Sicheng Xian Laijun Yan Guoqing Du Zhibi Shen Shuaijie Lv Hongsheng Zhan Zhengyan Li The correlation between coagulation biomarkers, bone turnover markers, and bone mineral density in Chinese adults aged ≥ 50 years Archives of Medical Science coagulation bone mineral density bone turnover marker correlation |
| title | The correlation between coagulation biomarkers, bone
turnover markers, and bone mineral density in Chinese
adults aged ≥ 50 years |
| title_full | The correlation between coagulation biomarkers, bone
turnover markers, and bone mineral density in Chinese
adults aged ≥ 50 years |
| title_fullStr | The correlation between coagulation biomarkers, bone
turnover markers, and bone mineral density in Chinese
adults aged ≥ 50 years |
| title_full_unstemmed | The correlation between coagulation biomarkers, bone
turnover markers, and bone mineral density in Chinese
adults aged ≥ 50 years |
| title_short | The correlation between coagulation biomarkers, bone
turnover markers, and bone mineral density in Chinese
adults aged ≥ 50 years |
| title_sort | correlation between coagulation biomarkers bone turnover markers and bone mineral density in chinese adults aged ≥ 50 years |
| topic | coagulation bone mineral density bone turnover marker correlation |
| url | https://www.archivesofmedicalscience.com/The-correlation-between-coagulation-biomarkers-bone-nturnover-markers-and-bone-mineral,184346,0,2.html |
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