Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study
Background: We conducted a nationwide population-based case-control study to analyse potential predisposing factors for hearing loss (HL) that present during the fetal, perinatal, and postnatal periods in prematurely born children. Methods: This study enrolled 21,576 children born at < 37 weeks o...
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Elsevier
2025-01-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957224000767 |
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| author | Pei-Chen Tsao Hung-Chih Lin Shang-Po Shen Yu-Chia Chang |
| author_facet | Pei-Chen Tsao Hung-Chih Lin Shang-Po Shen Yu-Chia Chang |
| author_sort | Pei-Chen Tsao |
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| description | Background: We conducted a nationwide population-based case-control study to analyse potential predisposing factors for hearing loss (HL) that present during the fetal, perinatal, and postnatal periods in prematurely born children. Methods: This study enrolled 21,576 children born at < 37 weeks of gestation; 3,596 with HL and 17,980 with normal hearing born between 2002 and 2015, matched for sex, age at diagnosis, and enrollment time. Data were abstracted from the concatenation of three nationwide databases for overall risk factors till the diagnosis of HL. Results: Maternal HL, maternal diabetes, particularly type 1 diabetes mellitus, and at or before 32 weeks of gestation were the major obstetric risk factors for HL. Prematurely born children who were born via cesarean section and received a combination of antenatal steroids and magnesium sulfate exhibited a significantly reduced risk of developing HL. Ear malformation was a critical predictor for HL. The major postnatal risk factors included seizure and ototoxic drugs use. Premature infants diagnosed with more than 1 diagnosis of bronchopulmonary dysplasia, necrotizing enterocolitis, and intracerebral hemorrhage were at an increased risk of developing HL. Congenital CMV infection and recurrent acute otitis were also independent postnatal factors for HL in prematurely born children. Conclusion: To reduce the incidence of childhood HL in prematurely born children, aggressive management of premature birth-related consequences and treatable causes and longitudinal audiological follow-up with early detection and adequate intervention are crucial. |
| format | Article |
| id | doaj-art-7dae01a1cc844f3594bb15e9bcf5fdbd |
| institution | Kabale University |
| issn | 1875-9572 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Pediatrics and Neonatology |
| spelling | doaj-art-7dae01a1cc844f3594bb15e9bcf5fdbd2025-01-25T04:11:04ZengElsevierPediatrics and Neonatology1875-95722025-01-016613743Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control studyPei-Chen Tsao0Hung-Chih Lin1Shang-Po Shen2Yu-Chia Chang3Department of Pediatrics, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Pediatrics, Taipei Veterans General Hospital, Taipei, TaiwanDivision of Neonatology, China Medical University Children’s Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan; Asia University Hospital, Asia University, Taichung, Taiwan; Corresponding author. Division of Neonatology, China Medical University Children’s Hospital, No. 2, Yude Rd., North Dist., Taichung City, 404327, Taiwan.Division of Neonatology, China Medical University Children’s Hospital, Taichung, TaiwanDepartment of Long-Term Care, College of Health and Nursing, National Quemoy University, Kinmen County, Taiwan; Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan; Corresponding author. Department of Long Term Care, College of Health and Nursing, National Quemoy University, No. 1, University Rd., Jinning Township, Kinmen County, 892, Taiwan.Background: We conducted a nationwide population-based case-control study to analyse potential predisposing factors for hearing loss (HL) that present during the fetal, perinatal, and postnatal periods in prematurely born children. Methods: This study enrolled 21,576 children born at < 37 weeks of gestation; 3,596 with HL and 17,980 with normal hearing born between 2002 and 2015, matched for sex, age at diagnosis, and enrollment time. Data were abstracted from the concatenation of three nationwide databases for overall risk factors till the diagnosis of HL. Results: Maternal HL, maternal diabetes, particularly type 1 diabetes mellitus, and at or before 32 weeks of gestation were the major obstetric risk factors for HL. Prematurely born children who were born via cesarean section and received a combination of antenatal steroids and magnesium sulfate exhibited a significantly reduced risk of developing HL. Ear malformation was a critical predictor for HL. The major postnatal risk factors included seizure and ototoxic drugs use. Premature infants diagnosed with more than 1 diagnosis of bronchopulmonary dysplasia, necrotizing enterocolitis, and intracerebral hemorrhage were at an increased risk of developing HL. Congenital CMV infection and recurrent acute otitis were also independent postnatal factors for HL in prematurely born children. Conclusion: To reduce the incidence of childhood HL in prematurely born children, aggressive management of premature birth-related consequences and treatable causes and longitudinal audiological follow-up with early detection and adequate intervention are crucial.http://www.sciencedirect.com/science/article/pii/S1875957224000767hearing lossmaternal-fetal risk factorspredisposing factorsprematurely born children |
| spellingShingle | Pei-Chen Tsao Hung-Chih Lin Shang-Po Shen Yu-Chia Chang Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study Pediatrics and Neonatology hearing loss maternal-fetal risk factors predisposing factors prematurely born children |
| title | Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study |
| title_full | Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study |
| title_fullStr | Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study |
| title_full_unstemmed | Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study |
| title_short | Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study |
| title_sort | exploring predisposing factors of hearing loss in prematurely born children a nationwide case control study |
| topic | hearing loss maternal-fetal risk factors predisposing factors prematurely born children |
| url | http://www.sciencedirect.com/science/article/pii/S1875957224000767 |
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