Botanicals as Modulators of Neuroplasticity: Focus on BDNF
The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/5965371 |
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| author | Enrico Sangiovanni Paola Brivio Mario Dell’Agli Francesca Calabrese |
| author_facet | Enrico Sangiovanni Paola Brivio Mario Dell’Agli Francesca Calabrese |
| author_sort | Enrico Sangiovanni |
| collection | DOAJ |
| description | The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored. The present review considers the literature on the effects of botanicals on BDNF. Botanicals considered were Bacopa monnieri (L.) Pennell, Coffea arabica L., Crocus sativus L., Eleutherococcus senticosus Maxim., Camellia sinensis (L.) Kuntze (green tea), Ginkgo biloba L., Hypericum perforatum L., Olea europaea L. (olive oil), Panax ginseng C.A. Meyer, Rhodiola rosea L., Salvia miltiorrhiza Bunge, Vitis vinifera L., Withania somnifera (L.) Dunal, and Perilla frutescens (L.) Britton. The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well. The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. Further clinical studies are mandatory to confirm botanicals as preventive agents or as useful adjuvant to the pharmacological treatment. |
| format | Article |
| id | doaj-art-7da109a60faf4e15b4c4edbcc6df4f33 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7da109a60faf4e15b4c4edbcc6df4f332025-02-03T00:59:15ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/59653715965371Botanicals as Modulators of Neuroplasticity: Focus on BDNFEnrico Sangiovanni0Paola Brivio1Mario Dell’Agli2Francesca Calabrese3Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, ItalyThe involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored. The present review considers the literature on the effects of botanicals on BDNF. Botanicals considered were Bacopa monnieri (L.) Pennell, Coffea arabica L., Crocus sativus L., Eleutherococcus senticosus Maxim., Camellia sinensis (L.) Kuntze (green tea), Ginkgo biloba L., Hypericum perforatum L., Olea europaea L. (olive oil), Panax ginseng C.A. Meyer, Rhodiola rosea L., Salvia miltiorrhiza Bunge, Vitis vinifera L., Withania somnifera (L.) Dunal, and Perilla frutescens (L.) Britton. The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well. The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. Further clinical studies are mandatory to confirm botanicals as preventive agents or as useful adjuvant to the pharmacological treatment.http://dx.doi.org/10.1155/2017/5965371 |
| spellingShingle | Enrico Sangiovanni Paola Brivio Mario Dell’Agli Francesca Calabrese Botanicals as Modulators of Neuroplasticity: Focus on BDNF Neural Plasticity |
| title | Botanicals as Modulators of Neuroplasticity: Focus on BDNF |
| title_full | Botanicals as Modulators of Neuroplasticity: Focus on BDNF |
| title_fullStr | Botanicals as Modulators of Neuroplasticity: Focus on BDNF |
| title_full_unstemmed | Botanicals as Modulators of Neuroplasticity: Focus on BDNF |
| title_short | Botanicals as Modulators of Neuroplasticity: Focus on BDNF |
| title_sort | botanicals as modulators of neuroplasticity focus on bdnf |
| url | http://dx.doi.org/10.1155/2017/5965371 |
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