Sex-specific NLRP3 activation in neutrophils promotes neutrophil recruitment and NETosis in the murine model of diffuse alveolar hemorrhage

Sex-specific NLRP3 activation in neutrophils promotes neutrophil recruitment and NETosis in the murine model of diffuse alveolar hemorrhage

ObjectivesDiffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus and small vessel vasculitis. We previously showed that neutrophil extracellular traps (NETs) were associated with the pathogenesis of pristane-induced DAH and demonstrated that neutrophil N...

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Bibliographic Details
Main Authors: Pierre-André Jarrot, Jiyoun Kim, William Chan, Lukas Heger, Nicolas Schommer, Pierre Cunin, Camila M. S. Silva, Stéphane Robert, Peter A. Nigrovic, Bruce Ewenstein, Denisa D. Wagner
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
NLRP3 inflammasome
neutrophil extracellular traps
diffuse alveolar hemorrhage
sexspecific
murine model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466234/full
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