The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness
Large mammals, including canids and felids, are affected by spontaneously occurring hereditary retinal diseases with similarities to those of humans. The large mammal models may be used for thorough clinical characterization of disease processes, understanding the effects of specific mutations, eluc...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2011/906943 |
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| author | Kristina Narfström Koren Holland Deckman Marilyn Menotti-Raymond |
| author_facet | Kristina Narfström Koren Holland Deckman Marilyn Menotti-Raymond |
| author_sort | Kristina Narfström |
| collection | DOAJ |
| description | Large mammals, including canids and felids, are affected by spontaneously occurring hereditary retinal diseases with similarities to those of humans. The large mammal models may be used for thorough clinical characterization of disease processes, understanding the effects of specific mutations, elucidation of disease mechanisms, and for development of therapeutic intervention. Two well-characterized feline models are addressed in this paper. The first model is the autosomal recessive, slowly progressive, late-onset, rod-cone degenerative disease caused by a mutation in the CEP290 gene. The second model addressed in this paper is the autosomal dominant early onset rod cone dysplasia, putatively caused by the mutation found in the CRX gene. Therapeutic trials have been performed mainly in the former type including stem cell therapy, retinal transplantation, and development of ocular prosthetics. Domestic cats, having large human-like eyes with comparable spontaneous retinal diseases, are also considered useful for gene replacement therapy, thus functioning as effective model systems for further research. |
| format | Article |
| id | doaj-art-7d9a84c5c59e41b6b1ae78cafdf8813e |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-7d9a84c5c59e41b6b1ae78cafdf8813e2025-02-03T01:31:08ZengWileyJournal of Ophthalmology2090-004X2090-00582011-01-01201110.1155/2011/906943906943The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal BlindnessKristina Narfström0Koren Holland Deckman1Marilyn Menotti-Raymond2Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, Mason Eye Institute, University of Missouri-Columbia, MO 65211, USADepartment of Chemistry, Gettysburg College, Gettysburg, PA 17325, USALaboratory of Genomic Diversity, National Cancer Institute-Frederick, Frederick, MD 21702-1201, USALarge mammals, including canids and felids, are affected by spontaneously occurring hereditary retinal diseases with similarities to those of humans. The large mammal models may be used for thorough clinical characterization of disease processes, understanding the effects of specific mutations, elucidation of disease mechanisms, and for development of therapeutic intervention. Two well-characterized feline models are addressed in this paper. The first model is the autosomal recessive, slowly progressive, late-onset, rod-cone degenerative disease caused by a mutation in the CEP290 gene. The second model addressed in this paper is the autosomal dominant early onset rod cone dysplasia, putatively caused by the mutation found in the CRX gene. Therapeutic trials have been performed mainly in the former type including stem cell therapy, retinal transplantation, and development of ocular prosthetics. Domestic cats, having large human-like eyes with comparable spontaneous retinal diseases, are also considered useful for gene replacement therapy, thus functioning as effective model systems for further research.http://dx.doi.org/10.1155/2011/906943 |
| spellingShingle | Kristina Narfström Koren Holland Deckman Marilyn Menotti-Raymond The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness Journal of Ophthalmology |
| title | The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness |
| title_full | The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness |
| title_fullStr | The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness |
| title_full_unstemmed | The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness |
| title_short | The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness |
| title_sort | domestic cat as a large animal model for characterization of disease and therapeutic intervention in hereditary retinal blindness |
| url | http://dx.doi.org/10.1155/2011/906943 |
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