CKD patients comorbid with hypertension are associated with imbalanced gut microbiome
Summary: Intestinal flora has been linked to chronic kidney disease (CKD) and hypertension, respectively. This study aimed to investigate the microbial community among 54 individuals without CKD, 46 hypertensive CKD patients (CKD_HTN), and 48 non-hypertensive CKD patients. Variations in microbial di...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225000252 |
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| author | Pan Wang Yang Shen Kaixin Yan Siyuan Wang Jie Jiao Hongjie Chi Jiuchang Zhong Qianmei Sun Ying Dong Jing Li |
| author_facet | Pan Wang Yang Shen Kaixin Yan Siyuan Wang Jie Jiao Hongjie Chi Jiuchang Zhong Qianmei Sun Ying Dong Jing Li |
| author_sort | Pan Wang |
| collection | DOAJ |
| description | Summary: Intestinal flora has been linked to chronic kidney disease (CKD) and hypertension, respectively. This study aimed to investigate the microbial community among 54 individuals without CKD, 46 hypertensive CKD patients (CKD_HTN), and 48 non-hypertensive CKD patients. Variations in microbial diversity were detected in CKD. The Prevotella-dominated type progressively increased from CKD to CKD_HTN. Based on the variation patterns, we identified six distinct clusters. Klebsiella, Turicibacter, and Enterobacter were enriched in CKD, whereas Escherichia and Mogibacterium were elevated, and Blautia and Clostridium were reduced in CKD_HTN. Enhanced phenylalanine metabolism and siderophore group nonribosomal peptides biosynthesis from non-CKD to CKD were observed, particularly in CKD with hypertension. The connections between genera and KEGG pathways suggest an impact of microbial dysbiosis on metabolism. Our findings demonstrate that imbalances in gut microorganisms and functions are associated with increased susceptibility to hypertension in CKD patients and could be targeted for improving kidney function in CKD. |
| format | Article |
| id | doaj-art-7d95b106d4a24095aa21318691a2d740 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-7d95b106d4a24095aa21318691a2d7402025-01-24T04:45:34ZengElsevieriScience2589-00422025-02-01282111766CKD patients comorbid with hypertension are associated with imbalanced gut microbiomePan Wang0Yang Shen1Kaixin Yan2Siyuan Wang3Jie Jiao4Hongjie Chi5Jiuchang Zhong6Qianmei Sun7Ying Dong8Jing Li9Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Corresponding authorHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Corresponding authorSummary: Intestinal flora has been linked to chronic kidney disease (CKD) and hypertension, respectively. This study aimed to investigate the microbial community among 54 individuals without CKD, 46 hypertensive CKD patients (CKD_HTN), and 48 non-hypertensive CKD patients. Variations in microbial diversity were detected in CKD. The Prevotella-dominated type progressively increased from CKD to CKD_HTN. Based on the variation patterns, we identified six distinct clusters. Klebsiella, Turicibacter, and Enterobacter were enriched in CKD, whereas Escherichia and Mogibacterium were elevated, and Blautia and Clostridium were reduced in CKD_HTN. Enhanced phenylalanine metabolism and siderophore group nonribosomal peptides biosynthesis from non-CKD to CKD were observed, particularly in CKD with hypertension. The connections between genera and KEGG pathways suggest an impact of microbial dysbiosis on metabolism. Our findings demonstrate that imbalances in gut microorganisms and functions are associated with increased susceptibility to hypertension in CKD patients and could be targeted for improving kidney function in CKD.http://www.sciencedirect.com/science/article/pii/S2589004225000252Molecular physiologyMicrobiologyMicrobiome |
| spellingShingle | Pan Wang Yang Shen Kaixin Yan Siyuan Wang Jie Jiao Hongjie Chi Jiuchang Zhong Qianmei Sun Ying Dong Jing Li CKD patients comorbid with hypertension are associated with imbalanced gut microbiome iScience Molecular physiology Microbiology Microbiome |
| title | CKD patients comorbid with hypertension are associated with imbalanced gut microbiome |
| title_full | CKD patients comorbid with hypertension are associated with imbalanced gut microbiome |
| title_fullStr | CKD patients comorbid with hypertension are associated with imbalanced gut microbiome |
| title_full_unstemmed | CKD patients comorbid with hypertension are associated with imbalanced gut microbiome |
| title_short | CKD patients comorbid with hypertension are associated with imbalanced gut microbiome |
| title_sort | ckd patients comorbid with hypertension are associated with imbalanced gut microbiome |
| topic | Molecular physiology Microbiology Microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225000252 |
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