An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival
Apoptosis resistance is a hallmark of human cancer, and tumor cells often become resistant due to defects in the programmed cell death machinery.Targeting key apoptosis regulators to overcome apoptotic resistance and promote rapid death of tumor cells is an exciting new strategy for cancer treatment...
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| Format: | Article |
| Language: | English |
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AIMS Press
2015-07-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1219 |
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| _version_ | 1832590126859943936 |
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| author | Alexis B. Cook Daniel R. Ziazadeh Jianfeng Lu Trachette L. Jackson |
| author_facet | Alexis B. Cook Daniel R. Ziazadeh Jianfeng Lu Trachette L. Jackson |
| author_sort | Alexis B. Cook |
| collection | DOAJ |
| description | Apoptosis resistance is a hallmark of human cancer, and tumor cells often become resistant due to defects in the programmed cell death machinery.Targeting key apoptosis regulators to overcome apoptotic resistance and promote rapid death of tumor cells is an exciting new strategy for cancer treatment, either alone or in combination with traditionally used anti-cancer drugs that target cell division. Here we present a multiscale modeling framework for investigating the synergism between traditional chemotherapy and targeted therapies aimed at critical regulators of apoptosis. |
| format | Article |
| id | doaj-art-7d93aaa9388743feb79f50f753aa862e |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-7d93aaa9388743feb79f50f753aa862e2025-01-24T02:33:57ZengAIMS PressMathematical Biosciences and Engineering1551-00182015-07-011261219123510.3934/mbe.2015.12.1219An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survivalAlexis B. Cook0Daniel R. Ziazadeh1Jianfeng Lu2Trachette L. Jackson3Department of Applied Mathematics, Brown University, 182 George Street, Providence, RI 02906Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109Department of Mathematics, University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1043Apoptosis resistance is a hallmark of human cancer, and tumor cells often become resistant due to defects in the programmed cell death machinery.Targeting key apoptosis regulators to overcome apoptotic resistance and promote rapid death of tumor cells is an exciting new strategy for cancer treatment, either alone or in combination with traditionally used anti-cancer drugs that target cell division. Here we present a multiscale modeling framework for investigating the synergism between traditional chemotherapy and targeted therapies aimed at critical regulators of apoptosis.https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1219cisplatin.multiscale modelcancer therapy |
| spellingShingle | Alexis B. Cook Daniel R. Ziazadeh Jianfeng Lu Trachette L. Jackson An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival Mathematical Biosciences and Engineering cisplatin. multiscale model cancer therapy |
| title | An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival |
| title_full | An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival |
| title_fullStr | An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival |
| title_full_unstemmed | An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival |
| title_short | An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival |
| title_sort | integrated cellular and sub cellular model of cancer chemotherapy and therapies that target cell survival |
| topic | cisplatin. multiscale model cancer therapy |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1219 |
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