PPAR Regulation of Inflammatory Signaling in CNS Diseases
Central nervous system (CNS) is an immune privileged site, nevertheless inflammation associates with many CNS diseases. Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone receptors that regulate immune and inflammatory responses. Specific ligands for PPAR𝛼, 𝛾, and 𝛿...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/658520 |
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| _version_ | 1832550983821950976 |
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| author | John J. Bright Saravanan Kanakasabai Wanida Chearwae Sharmistha Chakraborty |
| author_facet | John J. Bright Saravanan Kanakasabai Wanida Chearwae Sharmistha Chakraborty |
| author_sort | John J. Bright |
| collection | DOAJ |
| description | Central nervous system (CNS) is an immune privileged site, nevertheless inflammation associates with many CNS diseases. Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone receptors that regulate immune and inflammatory responses. Specific ligands for PPAR𝛼, 𝛾, and 𝛿 isoforms have proven effective in the animal models of multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease, and trauma/stroke, suggesting their use in the treatment of neuroinflammatory diseases. The activation of NF-𝜅B and Jak-Stat signaling pathways and secretion of inflammatory cytokines are critical in the pathogenesis of CNS diseases. Interestingly, PPAR agonists mitigate CNS disease by modulating inflammatory signaling network in immune cells. In this manuscript, we review the current knowledge on how PPARs regulate neuroinflammatory signaling networks in CNS diseases. |
| format | Article |
| id | doaj-art-7d79c80f669349a48d0b8811da9bdaac |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-7d79c80f669349a48d0b8811da9bdaac2025-02-03T06:05:22ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/658520658520PPAR Regulation of Inflammatory Signaling in CNS DiseasesJohn J. Bright0Saravanan Kanakasabai1Wanida Chearwae2Sharmistha Chakraborty3Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USANeuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USANeuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USANeuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USACentral nervous system (CNS) is an immune privileged site, nevertheless inflammation associates with many CNS diseases. Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone receptors that regulate immune and inflammatory responses. Specific ligands for PPAR𝛼, 𝛾, and 𝛿 isoforms have proven effective in the animal models of multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease, and trauma/stroke, suggesting their use in the treatment of neuroinflammatory diseases. The activation of NF-𝜅B and Jak-Stat signaling pathways and secretion of inflammatory cytokines are critical in the pathogenesis of CNS diseases. Interestingly, PPAR agonists mitigate CNS disease by modulating inflammatory signaling network in immune cells. In this manuscript, we review the current knowledge on how PPARs regulate neuroinflammatory signaling networks in CNS diseases.http://dx.doi.org/10.1155/2008/658520 |
| spellingShingle | John J. Bright Saravanan Kanakasabai Wanida Chearwae Sharmistha Chakraborty PPAR Regulation of Inflammatory Signaling in CNS Diseases PPAR Research |
| title | PPAR Regulation of Inflammatory Signaling in CNS Diseases |
| title_full | PPAR Regulation of Inflammatory Signaling in CNS Diseases |
| title_fullStr | PPAR Regulation of Inflammatory Signaling in CNS Diseases |
| title_full_unstemmed | PPAR Regulation of Inflammatory Signaling in CNS Diseases |
| title_short | PPAR Regulation of Inflammatory Signaling in CNS Diseases |
| title_sort | ppar regulation of inflammatory signaling in cns diseases |
| url | http://dx.doi.org/10.1155/2008/658520 |
| work_keys_str_mv | AT johnjbright pparregulationofinflammatorysignalingincnsdiseases AT saravanankanakasabai pparregulationofinflammatorysignalingincnsdiseases AT wanidachearwae pparregulationofinflammatorysignalingincnsdiseases AT sharmisthachakraborty pparregulationofinflammatorysignalingincnsdiseases |