First report on the synergy of Nepeta menthoides and Nepeta cephalotes essential oils for antimicrobial and preservation applications: A multi-ligand molecular docking simulation
The aim of this study was to investigate the chemical composition, antioxidant, antimicrobial, antibiofilm, cytotoxic effects, and multi-ligand docking of essential oils (EOs) from Nepeta menthoides (NM) and Nepeta cephalotes (NC), as well as their combined application (NM/NC) in the preservation of...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Applied Food Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772502225000174 |
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| author | Behrooz Alizadeh Behbahani Mohammad Noshad Fereshteh Falah Farshid Zargari Zahra Nikfarjam Alireza Vasiee |
| author_facet | Behrooz Alizadeh Behbahani Mohammad Noshad Fereshteh Falah Farshid Zargari Zahra Nikfarjam Alireza Vasiee |
| author_sort | Behrooz Alizadeh Behbahani |
| collection | DOAJ |
| description | The aim of this study was to investigate the chemical composition, antioxidant, antimicrobial, antibiofilm, cytotoxic effects, and multi-ligand docking of essential oils (EOs) from Nepeta menthoides (NM) and Nepeta cephalotes (NC), as well as their combined application (NM/NC) in the preservation of minced lamb. In this investigation, the impact of NM EOs, NC EOs, and their combination NM/NC on the chemical (pH, peroxide value (PV), and thiobarbituric acid index (TBARs)), microbial (total viable count (TVC), Escherichia coli, Staphylococcus aureus, and fungi), and sensory (odor, color, and overall acceptance) properties of refrigerated minced lamb was assessed over a 10-day period in comparison to the control sample. The primary component of the NM and NC EOs was determined to be neptalactone (35.90% in NM and 69.20% in NC). The EOs exhibited notable levels of total phenolic (106.90–133.40 mg GAE/g) and flavonoids (45.52–53.60 mg QE/g) contents, and demonstrated substantial antioxidant and antimicrobial effects. The multi-docking simulations across E. coli and S. aureus PDBs revealed varied categories and scores, illuminating distinctive ligand-receptor interactions. Statistical findings revealed that the escalation rates of pH, PV, TBARs, TVC, E. coli, S. aureus, and fungi in all treated samples were significantly lower than in the control. Results from the sensory analysis indicated a noteworthy preservation of odor, color, and overall acceptance in the EOs-treated minced lamb compared to the control sample during refrigerated storage. Minced lamb treated with 1% NM/NC combined EOs exhibited an extended shelf life in comparison to the other samples. |
| format | Article |
| id | doaj-art-7d72fb2d9df4480db912a61ebe1804df |
| institution | Kabale University |
| issn | 2772-5022 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Applied Food Research |
| spelling | doaj-art-7d72fb2d9df4480db912a61ebe1804df2025-01-22T05:44:23ZengElsevierApplied Food Research2772-50222025-06-0151100707First report on the synergy of Nepeta menthoides and Nepeta cephalotes essential oils for antimicrobial and preservation applications: A multi-ligand molecular docking simulationBehrooz Alizadeh Behbahani0Mohammad Noshad1Fereshteh Falah2Farshid Zargari3Zahra Nikfarjam4Alireza Vasiee5Department of Food Science and Technology, Faculty of Animal Science and Food Technology, Agricultural Sciences and Natural Resources University of Khuzestan, Mollasani, Iran; Corresponding author.Department of Food Science and Technology, Faculty of Animal Science and Food Technology, Agricultural Sciences and Natural Resources University of Khuzestan, Mollasani, IranDepartment of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, IranPharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan (USB), Zahedan, IranDepartment of Biology, Oberlin College, Oberlin, OH, USADepartment of Food Safety and Quality Control, Research Institute of Food Science and Technology (RIFST), Mashhad, IranThe aim of this study was to investigate the chemical composition, antioxidant, antimicrobial, antibiofilm, cytotoxic effects, and multi-ligand docking of essential oils (EOs) from Nepeta menthoides (NM) and Nepeta cephalotes (NC), as well as their combined application (NM/NC) in the preservation of minced lamb. In this investigation, the impact of NM EOs, NC EOs, and their combination NM/NC on the chemical (pH, peroxide value (PV), and thiobarbituric acid index (TBARs)), microbial (total viable count (TVC), Escherichia coli, Staphylococcus aureus, and fungi), and sensory (odor, color, and overall acceptance) properties of refrigerated minced lamb was assessed over a 10-day period in comparison to the control sample. The primary component of the NM and NC EOs was determined to be neptalactone (35.90% in NM and 69.20% in NC). The EOs exhibited notable levels of total phenolic (106.90–133.40 mg GAE/g) and flavonoids (45.52–53.60 mg QE/g) contents, and demonstrated substantial antioxidant and antimicrobial effects. The multi-docking simulations across E. coli and S. aureus PDBs revealed varied categories and scores, illuminating distinctive ligand-receptor interactions. Statistical findings revealed that the escalation rates of pH, PV, TBARs, TVC, E. coli, S. aureus, and fungi in all treated samples were significantly lower than in the control. Results from the sensory analysis indicated a noteworthy preservation of odor, color, and overall acceptance in the EOs-treated minced lamb compared to the control sample during refrigerated storage. Minced lamb treated with 1% NM/NC combined EOs exhibited an extended shelf life in comparison to the other samples.http://www.sciencedirect.com/science/article/pii/S2772502225000174Minced lamb preservationMulti-ligand dockingQuality propertiesSynergistic effect |
| spellingShingle | Behrooz Alizadeh Behbahani Mohammad Noshad Fereshteh Falah Farshid Zargari Zahra Nikfarjam Alireza Vasiee First report on the synergy of Nepeta menthoides and Nepeta cephalotes essential oils for antimicrobial and preservation applications: A multi-ligand molecular docking simulation Applied Food Research Minced lamb preservation Multi-ligand docking Quality properties Synergistic effect |
| title | First report on the synergy of Nepeta menthoides and Nepeta cephalotes essential oils for antimicrobial and preservation applications: A multi-ligand molecular docking simulation |
| title_full | First report on the synergy of Nepeta menthoides and Nepeta cephalotes essential oils for antimicrobial and preservation applications: A multi-ligand molecular docking simulation |
| title_fullStr | First report on the synergy of Nepeta menthoides and Nepeta cephalotes essential oils for antimicrobial and preservation applications: A multi-ligand molecular docking simulation |
| title_full_unstemmed | First report on the synergy of Nepeta menthoides and Nepeta cephalotes essential oils for antimicrobial and preservation applications: A multi-ligand molecular docking simulation |
| title_short | First report on the synergy of Nepeta menthoides and Nepeta cephalotes essential oils for antimicrobial and preservation applications: A multi-ligand molecular docking simulation |
| title_sort | first report on the synergy of nepeta menthoides and nepeta cephalotes essential oils for antimicrobial and preservation applications a multi ligand molecular docking simulation |
| topic | Minced lamb preservation Multi-ligand docking Quality properties Synergistic effect |
| url | http://www.sciencedirect.com/science/article/pii/S2772502225000174 |
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